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Testing Status of Sodium dichromate dihydrate (VI) M010079

 

CASRN: 7789-12-0

Formula: Cr2-O7.2Na.2H2-O

Synonyms/Common Names

  • Dichromic acid, disodium salt, dihydrate
  • Disodium dichromate dihydrate

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C20114)  Completed 
    • TOX-72 (NIH Number: 07-5964)
      Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/l; 10/sex/species.
  • 13 weeks (Dosed-Water)  (C20114B)  Completed 
    • TOX-72 (NIH Number: 07-5964)  (Tox Peer Review 07/05/2006A )
      Toxicity Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1 Mice and Male BALB/c and am3-C57BL/6 Mice
    • Mice: AM3 (C57BL/6); Mice: B6C3F1; Mice: BALB/c
    • Dose: Male Mice: 0, 62.5, 125, or 250 mg/l.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C20114)  Completed 
    • TR-546 (NIH Number: 08-5887)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Sodium Dichromate Dihydrate (CASRN 7789-12-0) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: M/F Rats and FM: 0, 14.3, 57.3, 172, or 516 mg/l; MM: 0, 14.3, 28.6, 85.7, or 258 mg/l.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage & Dosed-Water)  (S0941)  Completed 
    • Female Rats: F344/N; Female Mice: C57BL/6N
    • Dose: 1-100 mg/kg; 560 mg/L.
  • Toxicokinetic Study (Dosed-Water)  (S0830)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Guinea Pigs: Hartley
    • Dose: 0, 1, 3, 10, 30, 100, and 300 mg Cr/L.

Genetic Toxicology

  • Micronucleus  (A50434)  Completed 
    • Mice: BALB/c
    • Male Negative 
  • Micronucleus  (A54983)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A73280)  Completed 
    • Mice: AM3 (C57BL/6)
    • Male Positive 
  • Micronucleus  (A91250)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
  • Micronucleus  (A94686)  Completed 
    • Mice: AM3 (C57BL/6)
    • Male Negative 
  • Salmonella  (A06449)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (IMM20202)  Completed 
    • Female Rats/Mice: F344 And SD/B6C3F1
    • Dose: 0, 5, 20, OR 100 MG/L.