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Testing Status of Arsenic antioxidant mixture M010086

 

CASRN: ANTIOXCOMBO2

Secondary:

  • NAOSPINEXTR - Antioxidant model (TRAMP) - NAO (spinach extract)
  • NAOSPINEXTR - Natural antioxidant spinach leaf extract
  • 7784-46-5 - Sodium arsenite
  • 16561-29-8 - Tetradecanoyl phorbol acetate (TPA)
  • 58-95-7 - D-alpha-Tocopheryl acetate
  • 16561-29-8 - Transgenic LECM (Tetradecanoyl phorbol acetate (TPA))

Short-Term Toxicity

  • NTE 26 weeks (Dosed-Water)  (C20109)  Completed 
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: FEMALE MICE ONLY: TPA CONTROL (DERMAL); 150 MG/L SODIUM ARSENITE.
  • 26 weeks (Dosed-Water)  (C20109B)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: FEMALE MICE ONLY: (START DATES 7/00 AND 10/00) 0, 150, OR 200 MG/L SODIUM ARSENITE; NAO 80 MG/KG; VITAMIN E - 200 U/KG; TPA - .625 MG/UL; (START DATE 12/00) 0, 150, OR 200 MG/L SODIUM ARSENITE; NAO - 200 MG/KG; VITAMIN E - 200 U/KG; TPA - .625 MG/UL.