Testing Status of Resveratrol M010090
CASRN: 501-36-0
Formula: C14-H12-O3
Synonyms/Common Names
- 1,3-Benzenediol,5-(2-(4-hydroxyphenyl)ethenyl)-,(E)-
- NSC 327430
- 3,4',5-Stilbenetriol
- 3,4',5-Trihydroxystilbene
Short-Term Toxicity
- 2 weeks (Gavage)
(C20323)
Completed
- Rats: F344/NTac; Mice: B6C3F1
- Dose: Rats and mice: 0, 78(R), 156, 312, 625, 1250, or 2500(M) mg/kg; 5/sex/species.
- 13 weeks (Gavage)
(C20323)
Report in Preparation
- Rats: Wistar Han; Mice: B6C3F1
- Dose: Rats: 0, 78, 156, 312.5, 625, or 1250 mg/kg; 10/sex/dose; Mice: 0, 156, 312, 625, 1250, or 2500 mg/kg; 10/sex/dose.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C20323)
Data in Review
- Rats: Harlan Sprague-Dawley; Mice: B6C3F1
- Dose: Rats: 0, 312.5, 625, or 1250 mg/kg; 60/sex/dose @ 0 or 1250 mg/kg and 50/sex/dose @ 625 or 312.5; Mice: 0, 625, 1250, or 2500 mg/kg.
Modified One-Generation
- 3 weeks Developmental Toxicity (Gavage)
(MOG01090)
Data in Review
- Developmental toxicity
- Rats: Harlan Sprague-Dawley
- Dose: 0, 312.5, 625, or 1250 mg/kg.
- 8 weeks F0 Generation (Gavage)
(MOG01090)
Data in Review
- Rats: Harlan Sprague-Dawley
- Dose: 0, 312.5, 625, or 1250 mg/kg.
- 17 weeks Fertility Assessment (Gavage)
(MOG01090)
Data in Review
- Fertility assessment
- Rats: Harlan Sprague-Dawley
- Dose: 0, 312.5, 625, or 1250 mg/kg.
Special Studies
- Toxicokinetic Study (Gavage)
(K01090B)
Completed
- Pilot study
- Male and Female Rats: Wistar Han
- Dose: Dose adult (13 ± 2 weeks) male and female Wistar-Han rats with resveratrol by gavage at 78 mg/kg or 1250 mg/kg body weight (7 per dose group). Rats will be fed NTP 2000 diet. Dose timed-mated pregnant female Wistar-Han rats on gestation day 11-18 with resveratrol by gavage at 78 mg/kg or 1250 mg/kg body weight (6 per dose group). Dose Wistar-Han dams starting at gd 18 through pnd 4 with resveratrol at 78 mg/kg or 1250 mg/kg body weight (8 dams per dose group) pups on postnatal day 4.Pilot study developed to generate plasma and tissue samples..
- Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)
(K01090C)
Completed
- toxicokinetic studies of trans-resveratrol
- Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
- Dose: 0, 312.5, 625, and 1250 mg/kg. 10 mg/kg. 625, 1250, 2500 mg/kg.
Genetic Toxicology
- Micronucleus
(G01090)
Completed
- Rats: Wistar Han
- Male Negative
- Female Negative
- Micronucleus
(G01090B)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(A12955)
Completed
- Negative
Organ Systems Toxicity
- 180 days Immunotoxicity (Gavage)
(I01090)
Data in Review
- Assessment of the Ability of trans-Resveratrol to Modulate Type 1 Diabetes in Female Non-Obese Diabetic Mice
- Female Mice: NOD/MrKTac
- Dose: 0, 125, 250, 500, 1000 or 2000 mg/kg/day.
- 28 days Immunotoxicity (Gavage)
(IMM20704)
Data in Review
- Citation: Huang MC, White KL Jr, Elmore SA, Guo TL, Germolec D. Immunotoxicity studies of trans-resveratrol in male B6C3F1/N mice. J Immunotoxicol. 2020 Dec;17(1):194-201. doi: 10.1080/1547691X.2020.1833113.
- Male Mice: B6C3F1
- Dose: 0, 156, 312, 625, 1250, OR 2500 MG/KG/DAY.