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Testing Status of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) M020047

 

CASRN: 21850-44-2

Formula: C21-H20-Br8-O2

Synonyms/Common Names

  • Benzene, 1,1'-(1-methylethylidene)bis(3,5-dibromo-4-(2,3-dibromopropoxy)-(9CI)
  • Flame Retardant 2
  • Propane,2,2-bis[3,5-dibromo-4-(2,3-dibromopropoxy)phenyl]-8CI
  • TBBPA-DBPE

Short-Term Toxicity

  • 14-Day (Gavage)  (C02047B)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley
  • 13 weeks (Gavage)  (C20321)  Completed 
    • TOX-85 
      Toxicity Studies of Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (CASRN 21850-44-2) Administered by Gavage to F344/NTac Rats and B6C3F1/N Mice
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: R: 0, 62.5, 125, 250, 500, or 1000 mg/kg; 20/sex/dose M: 0, 125, 250, 500, 1000, or 2000 mg/kg; 10/sex/dose.

Special Studies

  • Metabolism (in-vitro)  (S0899)  Completed 
    • Citation: Knudsen GA, Jacobs LM, Kuester RK, Sipes IG. Absorption, distribution, metabolism and excretion of intravenously and orally administered tetrabromobisphenol A [2,3-dibromopropyl ether] in male Fischer-344 rats. Toxicology. 2007 Jul 31;237(1-3):158-67. Epub 2007 May 13. Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 20 mg/kg.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G02047)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G02047B)  On Test 
    • Human (Cell Lines)
  • Micronucleus  (A90104)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A44427)  Completed 
    •  Negative 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T02047)  Report in Preparation 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.