Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Green Tea Extract M030008



Synonyms/Common Names

  • GTE

Short-Term Toxicity

  • 5 days (Gavage)  (C03008)  Data in Review 
    • 5 day
    • Rats: F344/NCrl (SAS FISCH)
    • Dose: Green Tea Extract; 0, 3, 30, 100, 300, or 1000 mg/kg; 6 males/group.
  • 13 weeks (Gavage)  (C20203)  Completed 
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/kg; R: 20/sex/dose; M: 10/sex/dose.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20203)  Completed 
    • TR-585 (NIH Number: 16-5927)  (Peer Review Approval 05/22/2014A )
      Toxicology Studies of Green Tea Extract in F344/NTac Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Green Tea Extract in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: Wistar Han; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 100, 300, or 1, 000 mg/kg; M: 0, 30, 100, or 300 mg/kg; 50/sex/species/dose.

Genetic Toxicology

  • Micronucleus  (A70207)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • 5 days Micronucleus (Gavage)  (G03008)  Completed 
    • Rats: F344/N Charles River
  • Micronucleus Selected (G03008C)  
    • Human (Cell Lines)
  • Salmonella  (A43286)  Completed 
    •  Positive 
  • Salmonella Selected (G03008B)  


    • 5 days Microarray Analysis (Gavage)  (T03008)  Data in Review 
      • Rats: F344/NTac