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Testing Status of alpha-Pinene M030014

 

CASRN: 80-56-8

Formula: C10-H16

Synonyms/Common Names

  • Acintene A
  • Cyclic Dexadiene
  • 2-Pinene
  • 2,6,6-Trimethylbicyclo(3.1.1)-2-hept-2-ene

Secondary:

  • MONOTERPENES - Occupational Exposure Assessment of alpha-Pinene and related Monoterpenes

Short-Term Toxicity

  • 14 days (Inhalation)  (C20302)  Completed 
    • TOX-81 (NIH Number: 16-5937)
      Toxicity Studies of alpha-Pinene (CASRN 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 100, 200, 400, 800, or 1600 ppm; 5/sex/species/dose.
  • 7 days (Inhalation)  (C20302B)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 50 or 100 ppm, M: 0, 50 or 100 ppm.
  • 13 weeks (Inhalation)  (C20302)  Completed 
    • TOX-81 (NIH Number: 16-5937)
      Toxicity Studies of alpha-Pinene (CASRN 80-56-8) Administered by Inhalation to F344/N Rats and B6C3F1/N Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 25, 50, 100, 200, or 400 ppm; R: 20/sex/dose; M: 10/sex/dose.
  • 90 days (Inhalation)  (C20302B)  Data in Review 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 50, 100, 200 ppm.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C20302B)  On Test 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 50, 100, or 200 ppm 50/sex/exposure concentration; Mice: 0, 100, 200, or 400 ppm 50/sex exposure concentration.

Special Studies

  • 7 days Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K03014B)  On Test 
    • Male and Female Rats: Hsd:Sprague Dawley SD; Male and Female Mice: B6C3F1/N
    • Dose: 10 mg/kg [R,M]. 10, 50, 150 mg/kg. 50 mg/kg.

Genetic Toxicology

  • Micronucleus  (A82162)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A29697)  Completed 
    •  Negative 
  • 48 hours Salmonella (in-vitro)  (G03014)  Completed