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Testing Status of Sodium Tungstate Dihydrate M030038

 

CASRN: 10213-10-2

Formula: O4-W.2Na.2H2-O

Synonyms/Common Names

  • Sodium tungstate dihydrate
  • Tungstic acid, sodium salt, dihydrate

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C03038)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000, or 2000 mg/L; 10/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C03038)  Completed 
    • TR-599 
      Toxicology and Carcinogenesis Studies of Sodium Tungstate Dihydrate (CASRN 10213-10-2) in Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice (Drinking Water Studies)
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 250, 500, or 1000 mg/L; M: 0, 500, 1000, or 2000 mg/L; 50/sex/species/group.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Dosed-Water; Gavage; Dosed-Water)  (S0865)  Completed 
    • Citation: McDonald JD, Weber WM, Marr R, Kracko D, Khain H, Arimoto R. Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents. J Toxicol Environ Health A. 2007 May 15;70(10):829-36.Pubmed Abstract
    • Citation: Weber WM, Marr R, Kracko D, Gao Z, McDonald, JD. Disposition of tungsten in rodents after repeat oral and drinking water exposures. Toxicol. Environ. Chem. 2008 May-June;90(3):445-55
    • Female Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0, 1, 10, 100 mg/kg [R,M]. 560 mg/l [R,M].

Genetic Toxicology

  • Comet Assay (Gavage)  (G03038E)  Completed 
    • Mice: B6C3F1/N
  • Comet Assay (Gavage)  (G03038F)  Completed 
    • Rats: Harlan Sprague-Dawley
  • Micronucleus  (G03038B)  Completed 
    • MM: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G03038C)  Completed 
    • RR: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (G03038D)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (I03038)  Completed 
    • Citation: Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR. Immunotoxic effects of sodium tungstate dihydrate on female B6C3F1/N mice when administered in drinking water. J Immunotoxicol. 2016 Sep;13(5):666-75. doi: 10.3109/1547691X.2016.1154118. Epub 2016 May 25.
    • Female Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000 or 2000 mg/L.