Testing Status of Sodium Tungstate Dihydrate M030038

CASRN: 10213-10-2

Formula: O4-W.2Na.2H2-O

Synonyms/Common Names

• Sodium tungstate dihydrate
• Tungstic acid, sodium salt, dihydrate

Short-Term Toxicity

• 13 weeks (Dosed-Water)  (C03038)  Report in Preparation 
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
  • Dose: 0, 125, 250, 500, 1000, or 2000 mg/L; 10/sex/species/dose.

Long-Term Carcinogenicity

• 2 years (Dosed-Water)  (C03038)  Report in Preparation 
  • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
  • Dose: R: 0, 250, 500, or 1000 mg/L; M: 0, 500, 1000, or 2000 mg/L; 50/sex/species/group.

Special Studies

• Absorption Disposition Metabolism Elimination (Dosed-Water; Gavage)  (S0865)  Completed 
  • Citation: McDonald JD, Weber WM, Marr R, Kracko D, Khain H, Arimoto R. Disposition and clearance of tungsten after single-dose oral and intravenous exposure in rodents. J Toxicol Environ Health A. 2007 May 15;70(10):829-36.Pubmed Abstract
  • Citation: Weber WM, Marr R, Kracko D, Gao Z, McDonald, JD. Disposition of tungsten in rodents after repeat oral and drinking water exposures. Toxicol. Environ. Chem. 2008 May-June;90(3):445-55
  • Female Rats: F344/N; Female Mice: B6C3F1; Female Rats: F344/N; Female Mice: B6C3F1
  • Dose: 0, 1, 10, 100 mg/kg gavage ; 560 mg/l drinking water.

Genetic Toxicology

• Comet Assay (CO)  (G03038E)  Completed 
  • Mice
• Comet Assay (CO)  (G03038F)  Completed 
  • Rats
• Micronucleus  (G03038B)  Completed 
  • MM: B6C3F1
  • Male Negative 
  • Female Negative 
• Micronucleus  (G03038C)  Completed 
  • RR: Harlan Sprague-Dawley
  • Male Negative 
  • Female Negative 
• Salmonella  (G03038D)  Completed 
  •  Negative 

Organ Systems Toxicity

• 28 days Immunotoxicity (Dosed-Water)  (I03038)  Data in Review 
  • Female Mice: B6C3F1
  • Dose: 0, 125, 250, 500, 1000 or 2000 mg/L.