Testing Status of Triclosan M030039

CASRN: 3380-34-5

Synonyms/Common Names

• 2,4,4-Trichloro-2-hydroxydiphenyl ether

Short-Term Toxicity

• 4 days (Gavage)  (C03039)  Completed 
  • Liver Targeted Testing study of Toxcast Chemicals
  • Rats: Harlan Sprague-Dawley
  • Dose: Male rats: 0, 1000 mg/kg/day.
• 5 days (Gavage)  (C03039C)  Data in Review 
  • 5-Day Transcriptomic Dose-Response Studies
  • Rats: Harlan Sprague-Dawley
  • Dose: Male rats: 0, 7.8, 15.6, 31.25, 62.5, 125, 250, 500, or 1000 mg/kg; N=4.
• 90 days (Dermal)  (C03039B)  Completed 
  • Mice: B6C3F1
  • Dose: 0, 5.8, 12.5, 27, 58, or 125 mg/kg/bw/day; 10 M/ 10 F per dose.

Modified One-Generation

• GD 6 to PND 28 Dose Range Finding (Gavage)  (MOG03039)  Report in Preparation 
  • Perinatal
  • Rats: Harlan Sprague-Dawley
  • Dose: 0, 100, 250, 500, 1000, or 2000 mg/kg/day.

Special Studies

• Absorption Distribution Metabolism Excretion (Topical Application)  (K03039B)  Completed 
  • Male Mice: B6C3F1 (NCTR)
  • Dose: 10 and 100 mg/kg bwt.
• Toxicokinetic Study (Topical Application)  (K03039)  Completed 
  • Male Mice: B6C3F1 (NCTR)
  • Dose: 10 or 100 mg/kg bwt/day.

Genetic Toxicology

• 28 days Micronucleus (Gavage)  (G03039)  Completed 
  • Rats: Sprague Dawley
• 28 days Micronucleus (Transplacental & Gavage)  (G03039B)  Completed 
  • Rats: Harlan Sprague-Dawley

Toxicogenomics

• 4 days Microarray Analysis (Gavage)  (T03039)  Completed 
  • Liver Targeted Testing study of Toxcast Chemicals
  • Rats: Harlan Sprague-Dawley
  • Dose: 1000 mg/kg; 6 rats.
• 5 days Transcriptome Sequencing (Gavage)  (T03039B)  Data in Review 
  • 5-Day Transcriptomic Dose-Response Studies
  • Rats: Harlan Sprague-Dawley