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Testing Status of Deoxynivalenol M030040

 

CASRN: 51481-10-8

Formula: C15-H20-O6

Synonyms/Common Names

  • DON
  • Vomitoxin

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Gavage)  (MOG03040)  Report in Preparation 
    • Perinatal DRF study (MOG03040) of Deoxynivalenol (DON; CAS 51481-10-8) in Harlan Sprague Dawley (HSD) Rats Exposed via Oral Gavage
    • Citation: Huang MC, Furr JR, Robinson VG, Betz L, Shockley K, Cunny H, Witt K, Waidyanatha S, Germolec D. Oral deoxynivalenol toxicity in Harlan Sprague Dawley (Hsd:Sprague Dawley® SD®) rat dams and their offspring. Food Chem Toxicol. 2020 Dec 31;148:111963. doi: https://doi.org/10.1016/j.fct.2020.111963. Epub ahead of print.
    • Citation: Rehder Silinski MA, Gilliam JA, Fernando RA, Robinson VG, Germolec D, Cunny H, Huang MC, Furr J, Waidyanatha S. Development of an Analytical Method for Quantitation of Deoxynivalenol by UPLC-MS-MS: a Preliminary Assessment of Gestational and Lactational Transfer in Rats. J Anal Toxicol. 2020 Sep 4:bkaa119. doi: https://doi.org/10.1093/jat/bkaa119. Epub ahead of print.
    • Rats: Harlan Sprague Dawley (Indianapolis Facility)
    • Dose: 0, 0.03, 0.1, 0.3, 1, or 3 mg/kg/day.

Genetic Toxicology

  • 28 days Micronucleus (Gavage)  (G03040)  Completed 
    • Rats: Harlan Sprague-Dawley
  • 28 days Micronucleus (Gavage)  (G03040B)  Completed 
    • Rats: Harlan Sprague-Dawley
  • 28 days Micronucleus (Transplacental & Gavage)  (G03040C)  Completed 
    • Rats: Harlan Sprague-Dawley