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Testing Status of Perfluorohexanoic acid (PFHXA) M040048

 

CASRN: 307-24-4

Formula: C6-H-F11-O2

Synonyms/Common Names

  • C6 Carboxylic acid
  • Hexanoic acid, undecafluoro-

Short-Term Toxicity

  • 28 days (Gavage)  (C20613)  Completed 
    • TOX-97 
      Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: M&F: 0, 31.3, 62.5, 125, 250, or 500 mg/kg/2x day.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous)  (K10128)  Completed 
    • Citation: Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Gibbs ST, Granville CA, Blystone CR. Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration. Xenobiotica. 2019 Nov. DOI: 10.1080/00498254.2019.168376.Pubmed Abstract
    • Male and Female Rats: Hsd:Sprague Dawley SD

Genetic Toxicology

  • Micronucleus  (G04048)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Equivocal 
    • Female Negative 
  • Salmonella  (A97455)  Completed 
    •  Negative