Testing Status of Nanoscale material (Rutile titanium dioxide) M040087

CASRN: 1317-80-2

Formula: O2-Ti

Synonyms/Common Names

• Rutile titanium dioxide (Nanoscale material)

Short-Term Toxicity

• 2 weeks (Topical Application)  (C20408)  Completed 
  • Mice: Tg.AC (FVB/N) Hemizygous

Special Studies

• Absorption Disposition Metabolism Elimination (Intradermal Injection; Topical Application)  (S0975)  Completed 
  • Citation: Gao Y, Gopee NV, Howard PC, Yu LR. Proteomic analysis of early response lymph node proteins in mice treated with titanium dioxide nanoparticles. J Proteomics. 2011 Nov 18;74(12):2745-59. doi: 10.1016/j.jprot.2011.08.009. Epub 2011 Aug 22.Pubmed Abstract
  • Female Mice: SKH-1 Hairless
  • Dose: Exp. # 3Tape Stripped Skin [remove stratum corneum] 1. 5% in o/w emulsion, 2 mg/cm2Sunburned Skin [single dose of 120mJ-CIE/cm2 UVB light 48 hour prior to TiO2]1. 5% in o/w emulsion, 2 mg/cm2. Exp. #1[1] 5µl injections of the following:0.05 mg/mL [0.25 µg total]0.1 mg/mL [0.5 µg total]0.5 mg/mL [1.0 µg total]1.0 mg/mL [5.0 µg total]2.0 mg/mL [10 µg total][2] 5µl, 2mg/mL [10 µg total][3] 5µl, 2mg/mL [10 µg total]. Exp. #2Normal Skin5% in o/w emulsion, 2 mg/cm2, dorsal5% in o/w emulsion, 2 mg/cm2, axillary/inguinalDermabraded Skin5% in o/w emulsion, 2 mg/cm2, dorsal5% in o/w emulsion, 2 mg/cm2, axillary/inguinalIntradermal Injection0.5 mg/ml [depends on results of Exp. #1]. Exp. #4[1] 5µl injections of the following:0.05 mg/mL [0.25 µg total]0.1 mg/mL [0.5 µg total]0.5 mg/mL [1.0 µg total]1.0 mg/mL [5.0 µg total][2] 5µl, 1mg/mL [10 µg total][3] 5µl, 1mg/mL [10 µg total]. Exp. #5[1] vehicle: saline5µL, 2 mg/ml[2] vehicle: oil/water emulsionTBD by earlier studies.