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Testing Status of Ionic Liquid: 1-Butyl-3-methylimidazolium Chloride M050050

 

CASRN: 79917-90-1

Formula: C8-H15-Cl-N2

Synonyms/Common Names

  • (Bmim)Cl
  • 1-Butyl-3-methylimidazolium chloride (ionic liquid)

Short-Term Toxicity

  • 14 days (Dosed-Water)  (C05049)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: R: 0.3, 1, 3 mg/ml. M: 1, 3, 6 mg/ml. Common Controls for all studies.
  • 90 days (Dosed-Water)  (C50050)  Completed 
    • TOX-103 
      Toxicity Studies of Select Ionic Liquids (1-Ethyl-3-methylimidazolium chloride, 1-Butyl-3-methylimidazolium chloride, 1-Butyl-1-methylpyrrolidinium chloride, and N-butylpyridinium chloride) Administered in Drinking Water to Sprague Dawley (Hsd:Sprague Dawley SD) Rats and B6C3F1/N Mice
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 0.1, 0.3, or 1 mg/ml. M: 0, 0.3, 1, or 3 mg/ml. 10/sex/species.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Gavage; Intravenous; Topical Application)  (S0930)  Completed 
    • Citation: Sipes IG, Knudsen GA, Kuester RK. The effects of dose and route on the toxicokinetics and disposition of 1-butyl-3-methylimidazolium chloride in male F344 rats and female B6C3F1 mice. Drug Metab Dispos. 2008 Feb;36(2):284-93. Epub 2007 Oct 29. Pubmed Abstract
    • Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 0.5, 5.0, 50 mg/kg [R,M]. 5 mg/kg [R,M].
  • C. elegans  (W05050)  Completed 
    • C. elegans
    • Dose: Feeding: 0, 1, 4, 8, 12, 16, 20, 24, 28, 32, 36, 40 mM. Repro: 0, 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80 mM. Growth: 0, 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20 mM.

Genetic Toxicology

  • Micronucleus  (G05050)  Completed 
    • Male & Female Sprague Dawley Rats
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G05050B)  Completed 
    • Male & Female B6C3F1 Mice
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A33096)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Immunotoxicity (Topical Application)  (I05050)  Completed 
    • Citation: Frawley RP, Germolec DR, Johnson VJ, Gulledge T, Manheng W, White K Jr, Shockley KR, Harris SF, Hooth M, Ryan K. Evaluation of skin sensitization induced by four ionic liquids. J Appl Toxicol. 2022 Mar;42(3):392-408. https://doi.org/10.1002/jat.4224. Epub 2021 Aug 28.
    • Female Mice: BALB/c
    • Dose: 0, 3.12, 6.25, 12.5 or 25%.