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Testing Status of 2,2'-Dimorpholinodiethyl Ether M060065


CASRN: 6425-39-4

Formula: C12-H24-N2-O3

Synonyms/Common Names

  • 2,2'-Dimorpholinyldiethyl ether
  • Morpholine
  • Morpholine, 4,4'-(oxydi-2,1-ethanediyl)bis-

Short-Term Toxicity

  • 28 days (Gavage)  (C06065)  Data in Review 
    • 4-week Toxicity Study
    • Mice: B6C3F1/N
    • Dose: 0, 62.5, 125, 250, 500, or 1000 mg/kg/day.

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Gavage)  (MOG06065)  On Test 
    • Perinatal Investigative Study
    • Citation: Silinski MAR, Uenoyama T, Fernando RA, Robinson VG, Roberts G, Cunny H, Hubbard T, Waidyanatha S. Development of an Analytical Method for Quantitation of 2,2'-Dimorpholinodiethyl Ether (DMDEE) in Rat Plasma, Amniotic Fluid and Fetal Homogenate by UPLC-MS-MS for Determination of Gestational and Lactational Transfer in Rats. J Anal Toxicol. 2021 Nov 9;45(9):1036-1041. doi:
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 31.3, 62.5, 125, 250, or 500 mg/kg/day.

Special Studies

  • Absorption Distribution Metabolism Excretion (Dermal; Intravenous; Gavage; Dermal; Intravenous; Gavage)  (K06065)  Completed 
    • Citation: Waidyanatha S, McDonald JD, Sanders JM, Doyle-Eisele M, Moeller BC, Garner CE. Disposition and metabolism of 2,2'-dimorpholinodiethyl ether in sprague dawley rats and B6C3F1/N mice after oral, intravenous administration, and dermal application. Xenobiotica. 2020 Nov;50(11):1341-1351. doi: Epub 2020.Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley; Male and Female Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N; Male and Female Mice: B6C3F1/N
    • Dose: 10 mg/kg, males; 20 mg/kg, males and females; or 200 mg/kg, males. 20 mg/kg, males [R,M]. 20 mg/kg, males and females or 200 mg/kg, males.

Genetic Toxicology

  • Micronucleus (Gavage)  (G06065C)  Completed 
    • Mice: B6C3F1/N
  • Micronucleus (Gavage)  (G06065D)  Completed 
    • Rats: Sprague Dawley
  • Salmonella  (G06065)  Completed 
    •  Negative 
  • Salmonella  (G06065B)  Completed