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Testing Status of Nanoscale material (Fullerene-C60 1 micron) M070010

 

CASRN: 99685-96-8

Formula: C60

Synonyms/Common Names

  • Fullerene-C60 1 micron (Nanoscale material)

Short-Term Toxicity

  • 90 days (Inhalation)  (C20701)  Report in Preparation 
    • Citation: Sayers BC, Germolec DR, Walker NJ, Shipkowski KA, Stout MD, Cesta MF, Roycroft JH, White KL, Baker GL, Dill JA, Smith MJ. Respiratory toxicity and immunotoxicity evaluations of microparticle and nanoparticle C60 fullerene aggregates in mice and rats following nose-only inhalation for 13 weeks. Nanotoxicology. 2016 Dec;10(10):1458-1468. Epub 2016 Sep 30. https://doi.org/10.1080/17435390.2016.1235737
    • Rats: Wistar Han; Mice: B6C3F1
    • Dose: R&M: 0, 2, 15, or 30 mg/m3; R: 20/sex/dose; M: 10/sex/dose.

Genetic Toxicology

  • Micronucleus  (G07010B)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G07010)  Completed 
    • Rats: Wistar Han
    • Male Negative 
    • Female Negative 

Organ Systems Toxicity

  • Varies Immunotoxicity (Inhalation)  (I20710B)  Completed 
    • Male and Female Mice: B6C3F1
    • Dose: 0, 2, 15 or 30 mg/m3.
  • Varies Immunotoxicity (Inhalation)  (I20710)  Completed 
    • Male and Female Rats: Wistar Han
    • Dose: 1 micron: 0, 2, 15 or 30 mg/m3.