ortho-Phthalaldehyde (643-79-8)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID6032514

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to ortho-Phthalaldehyde (643-79-8).
Micronucleus - Rats
View Male: Negative Female: Negative

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to ortho-Phthalaldehyde (643-79-8).
Micronucleus - Mice
View Male: Equivocal Female: Negative

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to ortho-Phthalaldehyde (643-79-8).
Bacterial Mutagenicity
View Positive

Citation Information

NTP. ortho-Phthalaldehyde (643-79-8). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

TOX-84 Toxicity Studies of ortho-Phthalaldehyde (CASRN 643-79-8) Administered by Whole Body Exposure to Harlan Sprague Dawley Rats and B6C3F1/N Mice

Evaluation of the Respiratory Tract Toxicity of <i>ortho</i>-Phthalaldehyde, a Proposed Alternative for the Chemical Disinfectant Glutaraldehyde Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
Inhalation Toxicology (2017). DOI: https://doi.org/10.1080/08958378.2017.1390015 PMID: 29039228

Study Data

Protocol

Toxicity and Carcinogenicity Studies

Data

3-Month Evaluation of the Toxicity (C20727) of ortho-Phthalaldehyde (643-79-8) in Harlan Sprague-Dawley Rats via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (66 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (19 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (44 kB)
P04 - Neoplasms by Individual Animal (265 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (348 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (379 kB)
P11 - Statistical Analysis of Survival Data (28 kB)
P14 - Individual Animal Pathology Data (384 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (46 kB)
P40 - Survival Curves (59 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (34 kB)
Female Individual Animal Clinical Observations (10 kB)
Female Individual Animal Non Neoplastic Pathology Data (228 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (35 kB)
Male Individual Animal Clinical Observations (11 kB)
Male Individual Animal Non Neoplastic Pathology Data (272 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Data

3-Month Evaluation of the Toxicity (C20727) of ortho-Phthalaldehyde (643-79-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

E03 - Growth Curves (65 kB)
E04 - Mean Body Weights and Survival Table (18 kB)
E05 - Clinical Observations Summary (19 kB)
P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (41 kB)
P04 - Neoplasms by Individual Animal (264 kB)
P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (35 kB)
P09 - Non-Neoplastic Lesions by Individual Animal (323 kB)
P10 - Statistical Analysis of Non-Neoplastic Lesions (307 kB)
P11 - Statistical Analysis of Survival Data (28 kB)
P14 - Individual Animal Pathology Data (380 kB)
P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (42 kB)
P40 - Survival Curves (59 kB)

Individual Animal Data

Female Individual Animal Body Weight Data (33 kB)
Female Individual Animal Clinical Observations (20 kB)
Female Individual Animal Non Neoplastic Pathology Data (227 kB)
Female Individual Animal Organ Weight Data (19 kB)
Female Individual Animal Survival Data (11 kB)
Male Individual Animal Body Weight Data (33 kB)
Male Individual Animal Clinical Observations (19 kB)
Male Individual Animal Non Neoplastic Pathology Data (230 kB)
Male Individual Animal Organ Weight Data (19 kB)
Male Individual Animal Survival Data (11 kB)

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of ortho-Phthalaldehyde (643-79-8) in Micronucleus Study G07036B in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (71 KB)
Individual Animal In Vivo Micronucleus Data (9 KB)

Data

Genetic Toxicity Evaluation of ortho-Phthalaldehyde (643-79-8) in Micronucleus Study G07036C in B6C3F1 Mice

Summary and Individual Animal Data

G04 - In Vivo Micronucleus Summary Data (72 KB)
Individual Animal In Vivo Micronucleus Data (9 KB)

Data

Genetic Toxicity Evaluation of ortho-Phthalaldehyde in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G07036

Summary Data

G06 - Ames Summary Data (78 KB)

ortho-Phthalaldehyde (643-79-8)

Study Results

Genetic Toxicology

Citation Information

Related Links

Publications

Study Data

Toxicity and Carcinogenicity Studies

3-Month Evaluation of the Toxicity (C20727) of ortho-Phthalaldehyde (643-79-8) in Harlan Sprague-Dawley Rats via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

3-Month Evaluation of the Toxicity (C20727) of ortho-Phthalaldehyde (643-79-8) in B6C3F1 Mice via Whole Body Respiratory Exposure

Study Tables

Individual Animal Data

Genetic Toxicology Studies

Genetic Toxicity Evaluation of ortho-Phthalaldehyde (643-79-8) in Micronucleus Study G07036B in Harlan Sprague-Dawley Rats

Summary and Individual Animal Data

Genetic Toxicity Evaluation of ortho-Phthalaldehyde (643-79-8) in Micronucleus Study G07036C in B6C3F1 Mice

Summary and Individual Animal Data

Genetic Toxicity Evaluation of ortho-Phthalaldehyde in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G07036

Summary Data

NTP Data Collections