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Testing Status of Dimethylamine Borane M070051

 

CASRN: 74-94-2

Formula: C2-H10-B-N

Synonyms/Common Names

  • Borane, compd. with dimethylamine (1:1)
  • Boron, trihydro(N-methylmethanamine)-, (beta-4)-
  • DMAB

Short-Term Toxicity

  • 2 weeks (Dermal)  (C07051)  Report in Preparation 
    • Dose range finding
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
    • Dose: R: 0, 15.6, 31.25, 62.5, 125 or 250 mg/kg; 5/sex/group; MM: 0, 15.6, 31.25, 62.5, 125 or 250 mg/kg; 5/sex/group; FM: 0, 31.25, 62.5, 125, 250 or 500 mg/kg; 5/sex/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application; Intravenous; in-vitro)  (K07051)  Completed 
    • Citation: Mathews JM, Watson SL, Patel PR, Black SR, Hong Y, Levine KE, Ross G, Germolec DR, Thakur SA, Waidyanatha S. Metabolism and disposition of [(14)C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application. Xenobiotica. 2014 Jan;44(1):36-47. doi: 10.3109/00498254.2013.800662.Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley; Human (Cell Lines)
    • Dose: In vitro; 0.054 and 0.54 mg. gavage; 1.5 mg/kg. intravenous; 1.5 mg/kg. topical; 0.15, 1.5, 15 mg/kg.

Genetic Toxicology

  • Salmonella  (G07051)  Completed 
    •  Weakly Positive 
  • Salmonella  (G07051B)  Completed 
    •  Weakly Positive 

Organ Systems Toxicity

  • 3 to 7 days Immunotoxicity (Topical Application)  (I07051)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 5, 10, 25, or 50%.