Testing Status of Dimethylamine Borane M070051
CASRN: 74-94-2
Formula: C2-H10-B-N
Synonyms/Common Names
- Borane, compd. with dimethylamine (1:1)
- Boron, trihydro(N-methylmethanamine)-, (beta-4)-
- DMAB
Short-Term Toxicity
- 2 weeks (Dermal)
(C07051)
Report in Preparation
- Dose range finding
- Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
- Dose: R: 0, 15.6, 31.25, 62.5, 125 or 250 mg/kg; 5/sex/group; MM: 0, 15.6, 31.25, 62.5, 125 or 250 mg/kg; 5/sex/group; FM: 0, 31.25, 62.5, 125, 250 or 500 mg/kg; 5/sex/group.
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; in-vitro)
(K07051)
Completed
- Citation: Mathews JM, Watson SL, Patel PR, Black SR, Hong Y, Levine KE, Ross G, Germolec DR, Thakur SA, Waidyanatha S. Metabolism and disposition of [(14)C]dimethylamine borane in male Harlan Sprague Dawley rats following gavage administration, intravenous administration and dermal application. Xenobiotica. 2014 Jan;44(1):36-47. doi: 10.3109/00498254.2013.800662.Pubmed Abstract
- Male Rats: Harlan Sprague-Dawley; Human (Cell Lines)
- Dose: 0.054 and 0.54 mg. 0.15, 1.5, 15 mg/kg. 1.5 mg/kg.
Genetic Toxicology
- Salmonella
(G07051)
Completed
- Weakly Positive
- Salmonella
(G07051B)
Completed
- Weakly Positive
Organ Systems Toxicity
- 3 to 7 days Immunotoxicity (Topical Application)
(I07051)
Completed
- Female Mice: BALB/c
- Dose: 0, 5, 10, 25, or 50%.