Testing Status of Ethinyl estradiol M200009
CASRN: 57-63-6
Formula: C20-H24-O2
Synonyms/Common Names
- 19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol, (17alpha)-
Short-Term Toxicity
- 5 days (Gavage)
(C20009B)
Completed
- 5-Day Transcriptomic Dose-Response Studies
- Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
- Rats: Harlan Sprague-Dawley
- Dose: Female rats: 0, 0.02, 0.067, 0.2, 0.6, 1.8, 5.4, 16.2, or 48.6 mcg/kg; N=4. Male rats: 0, 0.02, 0.067, 0.2, 0.6, 1.8, 5.4, 16.2, or 48.6 mcg/kg; N=4.
- 5 days (Gavage)
(C20009B)
Data in Review
- Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
- Rats: Harlan Sprague-Dawley
- Dose: Female rats: 0, 0.02, 0.067, 0.2, 0.6, 1.8, 5.4, 16.2, or 48.6 mcg/kg; N=4. Male rats: 0, 0.02, 0.067, 0.2, 0.6, 1.8, 5.4, 16.2, or 48.6 mcg/kg; N=4.
Genetic Toxicology
- Micronucleus
(A39469)
Completed
- Mice: FVB/N
- Male Negative
- Female Negative
- Micronucleus
(A51448)
Completed
- Mice: FVB/N
- Male Negative
- Female Negative
- Micronucleus
(A93135)
Completed
- Mice: Tg.AC (FVB/N) Homozygous
- Male Negative
- Female Negative
- Micronucleus
(A99151)
Completed
- Mice: Tg.AC (FVB/N) Homozygous
- Male Negative
- Female Negative
- Salmonella
(018582)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
- Negative
- Salmonella
(N-9099)
Completed
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
- Citation: Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol Environ. Mutagen. Vol. 6 (Suppl 2) (1984) 1-251
Toxicogenomics
- 5 days Transcriptome Sequencing (Gavage)
(T20009)
Completed
- 5-Day Transcriptomic Dose-Response Studies
- Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
- Rats: Harlan Sprague-Dawley
- 5 days Transcriptome Sequencing (Gavage)
(T20009)
Data in Review
- Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
- Rats: Harlan Sprague-Dawley