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Testing Status of Triclocarban M200069

 

CASRN: 101-20-2

Formula: C13-H9-Cl3-N2-O

Synonyms/Common Names

  • Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)- (9CI)

Special Studies

  • Absorption Disposition Metabolism Elimination (Dermal; Gavage; Dermal; Gavage; in-vitro)  (K20069)  Completed 
    • Citation: Waidyanatha S, Black SR, Patel PR, Watson SL, Snyder RW, Sutherland V, Stanko J, Fennell TR. Disposition and metabolism of antibacterial agent, triclocarban, in rodents; a species and route comparison. Xenobiotica. 2020 Dec;50(12):1469-1482. doi: https://doi.org/10.1080/00498254.2020.1779391. Epub 2020 Jun 24.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: Gavage 50, 150, or 500 mg/kg. Topical Application 1.5 or 3 %. in vitro 1 uM.
  • C. elegans  (W20069)  Completed 
    • C. elegans
    • Dose: 100, 75, 50 uM.

Genetic Toxicology

  • Salmonella  (221813)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative