Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Methacrylonitrile M20116

 

CASRN: 126-98-7

Formula: C4-H5-N

Synonyms/Common Names

  • MAN
  • 2-Propenenitrile, 2-methyl- (9CI)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C88050)  Completed 
    • TOX-47 (NIH Number: 00-4403)
      Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 0.3, 0.6, 1.2, 2.4, 4.8 G/L; M: 0, 0.15, 0.3, 0.6, 1.2, 2.4 G/L; 5/GRP.
  • 13 weeks (Gavage)  (C88050)  Completed 
    • TOX-47 (NIH Number: 00-4403)  (Tox Peer Review 11/08/1999A )
      Toxicity Studies of Methacrylonitrile Administered by Gavage to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R: 0, 7.5, 15.0, 30.0, 60.0, 120.0 MG/KG/DAY; M: 0, 0.75, 1.5, 3.0, 6.0, 12.0 MG/KG/DAY; RATS: 20/GRP; MICE: 10/GRP.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C88050B)  Completed 
    • TR-497 (NIH Number: 02-4431)  (Peer Review Approval 05/03/2001A )
      Toxicology and Carcinogenesis Studies of Methacrylonitrile (CASRN 126-98-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: RATS: 0, 3, 10, OR 30 MG/KG MICE: 0, 1.5, 3, OR 6 MG/KG; 50/SEX/DOSE/SPECIES.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage)  (S0679)  Completed 
    • Citation: Ghanayem BI, Sanchez IM, Burka LT. Effects of dose, strain, and dosing vehicle on methacrylonitrile disposition in rats and identification of a novel-exhaled metabolite. Drug Metab Dispos. 1992 Sep-Oct;20(5):643-52.Pubmed Abstract
    • Male Rats: F344/N; Male Rats: Sprague Dawley
    • Dose: 1.15, 11.5, 115 mg/kg.
  • Absorption Distribution Metabolism Excretion (Gavage)  (S0730)  Completed 
    • Citation: Burka LT, Sanchez IM, Ahmed AE, Ghanayem BI. Comparative metabolism and disposition of acrylonitrile and methacrylonitrile in rats. Arch Toxicol. 1994;68(10):611-8.Pubmed Abstract
    • Male Rats: Fischer 344
    • Dose: 58 mg/kg.
  • Metabolism  (S0727)  Completed 
    • Citation: Ghanayem BI, Burka LT. Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats. Drug Metab Dispos. 1996 Apr;24(4):390-4.Pubmed Abstract
    • Male Rats: F344/N
  • Other  (S0728)  Completed 
    • Citation: Demby KB, White TC, Ghanayem BI. Determination of methacrylonitrile in serum using gas chromatography and flame ionization detection. J Chromatogr. 1992 Aug 7;579(1):153-7.Pubmed Abstract
  • Toxicokinetic Study  (S0729)  Completed 
    • Citation: Demby KB, Sanchez IM, Ghanayem BI. Single dose blood toxicokinetics of methacrylonitrile in the F344 rat. Toxicol Appl Pharmacol. 1993 Mar;119(1):115-21.Pubmed Abstract
    • Male Rats: F344/N

Genetic Toxicology

  • Drosophila  (042416)  Completed 
    • Citation: Zimmering, S., Mason, J.M., and Valencia, R. Chemical mutagenesis testing in Drosophila. VII. Results of 22 coded compounds tested in larval feeding experiments. Environ. Molec. Mutagen. Vol. 14 (1989) 245-252
    • Reciprocal Translocation/Sex-Linked Recessive Lethal Negative 
  • Micronucleus  (A05400)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Micronucleus  (A38969)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A63179)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (799133)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (926215)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • 16 weeks Continuous Breeding (Legacy) (Gavage)  (RACB94019)  Completed 
    • Male and Female Rats: Sprague Dawley
    • Dose: 0, 2, 7, OR 20 MG/KG.
  • Conventional Teratology (Gavage)  (TER92117)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in Sprague-Dawley Rats
    • Rats: Sprague Dawley
    • Rats Maternal Negative 
    • Rats Fetal Negative 
    • Dose: 0, 5, 25, 50 MG/KG GD: 6-15.
  • 6 to 19 GD Conventional Teratology (Gavage)  (TER92122)  Completed 
    • Citation: Final Report on the Developmental Toxicity of Methacrylonitrile in New Zealand White Rabbits
    • Rabbits: New Zealand White
    • Rabbits Maternal Negative 
    • Rabbits Fetal Negative 
    • Dose: 0, 1, 3, 5 MG/KG/DAY.
  • Teratology Pilot Studies (Gavage)  (TRP91020)  Completed 
    • Rabbits: New Zealand White
    • Dose: 0, 5, 10, 25, 50, 75 MG/KG.
  • 6 to 15 GD Teratology Pilot Studies (Gavage)  (TRP91021)  Completed 
    • Female Rats: Sprague Dawley
    • Dose: 0, 10, 50, 75, 100, 125 MG/KG.
  • 6 to 19 GD Teratology Pilot Studies (Gavage)  (TRP92058)  Completed 
    • Female Rabbits: New Zealand White
    • Dose: 0 OR 7.5 MG/KG.