Testing Status of Methapyrilene hydrochloride M20123

1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-, monohydrochloride (9CI)

14-Day (Dosed-Feed) (C55550D) Completed
- Rats: F344/N; Mice: B6C3F1
13-Week (Dosed-Feed) (C55550D) Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R: 0, 100, OR 1200, M: 0, 500, OR 8000 PPM/24 PER GROUP.
13 weeks (Dosed-Feed) (C55550E) Completed
- TOX-46 (NIH Number: 00-4407) (Tox Peer Review 12/00/1999A )
  Hepatoxicity Studies of the Liver Carcinogen Methapyrilene Hydrochloride Administered in Feed to Male F344/N Rats
- Rats: F344/N
- Dose: MALE RATS: 0, 50, 100, 250, 1000 PPM; 40/GRP.

6 weeks (Dosed-Feed) (C55550A) Completed
- (Peer Review Approval 05/01/1979A ) Citation: W Lijinsky, MD Reuber, BN Blackwell, Liver Tumors Induced in Rats by Oral Administration of the Antihistaminic Methapyrilene Hydrochloride. Science 209:817-819 (1980)
- Rats: F344/N; Mice: B6C3F1

In Vitro Cytogenetics (CA/SCE) (184622) Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
Mouse Lymphoma (860299) Completed
- Citation: McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
- Mice
- Negative
Salmonella (769480) Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative