U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Methapyrilene hydrochloride (135-23-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID0020818


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Methapyrilene hydrochloride (135-23-9).
Mammalian Cell Mutagenicity
View
  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Methapyrilene hydrochloride (135-23-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Methapyrilene hydrochloride (135-23-9).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Methapyrilene hydrochloride (135-23-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


W Lijinsky, MD Reuber, BN Blackwell, Liver Tumors Induced in Rats by Oral Administration of the Antihistaminic Methapyrilene Hydrochloride. Science 209:817-819 (1980)
TOX-46 Hepatoxicity Studies of the Liver Carcinogen Methapyrilene Hydrochloride (CASRN 135-23-9) Administered in Feed to Male F344/N Rats
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Female F344 Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C55550E) of Methapyrilene hydrochloride (135-23-9) in F344 Rats Exposed via Dosed Feed. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of Methapyrilene Hydrochloride (135-23-9) in Female B6C3F1 Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C55550E) of Methapyrilene Hydrochloride (135-23-9) in F344/N Rats Exposed via Dosed Feed