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Testing Status of Diazoaminobenzene M20124

 

CASRN: 136-35-6

Formula: C12-H11-N3

Synonyms/Common Names

  • DAAB
  • 1-Triazene, 1,3-diphenyl-

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C96002)  Completed 
    • TOX-73 (NIH Number: 02-4412)
      Metabolism, Toxicity, and Predicted Carcinogenicity Studies of Diazoaminobenzene Administered Dermally to F344/N Rats and B6C3F1 Mice
    • Rats: F344/N; Mice: B6C3F1
    • Dose: 0, 12.5, 25, 50, 100, OR 200 MG/KG B.W..

Special Studies

  • Toxicokinetic Study (Dosed-Feed)  (S0638)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: oral: 20 mg/kg dermal: 2, 20 mg/cm2 iv: 2 mg/kg.

Genetic Toxicology

  • Micronucleus  (A64807)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
    • Mice: B6C3F1
    • Male Positive 
  • Micronucleus  (A72640)  Completed 
    • Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
    • Mice: B6C3F1
    • Male Positive 
  • Salmonella  (529702)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Positive 

in vitro Testing

  • Bovine Corneal Opacity and Premeability Assay (Gavage)  (IVT20003A)  Completed 
    • Mice: B6C3F1
  • Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model (Gavage)  (IVT20003B)  Completed 
    • Mice: B6C3F1
  • Alternate (Intravenous)  (IVT20003B)   
    • Rats: F344/N
  • Neutral Red Uptake Bioassay (Gavage)  (IVT20003C)  Completed 
    • Mice: B6C3F1/N; Rats: F344/N
  • Alternate (Dosed-Feed)  (IVT20003D)   
    • Mice: B6C3F1
  • Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes (Dosed-Feed)  (IVT20003D)  Completed 
    • Rats: F344/N