Testing Status of Diazoaminobenzene M20124
CASRN: 136-35-6
Formula: C12-H11-N3
Synonyms/Common Names
- DAAB
- 1-Triazene, 1,3-diphenyl-
Short-Term Toxicity
- 2 weeks (Topical Application)
(C96002)
Completed
- TOX-73 (NIH Number: 02-4412)
Metabolism, Toxicity, and Predicted Carcinogenicity Studies of Diazoaminobenzene Administered Dermally to F344/N Rats and B6C3F1 Mice - Rats: F344/N; Mice: B6C3F1
- Dose: 0, 12.5, 25, 50, 100, OR 200 MG/KG B.W..
- TOX-73 (NIH Number: 02-4412)
Special Studies
- Toxicokinetic Study (Dosed-Feed)
(S0638)
Completed
- Male Rats: F344/N; Male Mice: B6C3F1
- Dose: oral: 20 mg/kg dermal: 2, 20 mg/cm2 iv: 2 mg/kg.
Genetic Toxicology
- Micronucleus
(A64807)
Completed
- Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
- Mice: B6C3F1
- Male Positive
- Micronucleus
(A72640)
Completed
- Citation: Ress NB, Witt KL, Xu J, Haseman JK, Bucher JR. Micronucleus induction in mice exposed to diazoaminobenzene or its metabolites, benzene and aniline: implications for diazoaminobenzene carcinogenicity. Mutation Res. Vol. 521 (2002) 201 - 208
- Mice: B6C3F1
- Male Positive
- Salmonella
(529702)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Positive
in vitro Testing
- Bovine Corneal Opacity and Premeability Assay (Gavage)
(IVT20003A)
Completed
- Mice: B6C3F1
- Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model (Gavage)
(IVT20003B)
Completed
- Mice: B6C3F1
- Alternate (Intravenous)
(IVT20003B)
- Rats: F344/N
- Neutral Red Uptake Bioassay (Gavage)
(IVT20003C)
Completed
- Mice: B6C3F1/N; Rats: F344/N
- Alternate (Dosed-Feed)
(IVT20003D)
- Mice: B6C3F1
- Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes (Dosed-Feed)
(IVT20003D)
Completed
- Rats: F344/N