Testing Status of Benzidine dihydrochloride M20140

CASRN: 531-85-1

Related: BENZIDINE 92-87-5

Formula: C12-H12-N2.2Cl-H

Synonyms/Common Names

• (1,1'-Biphenyl)-4,4'-diamine, dihydrochloride

Short-Term Toxicity

• 13-Week (Dosed-Water)  (C03361)  Completed 
  • Rats: F344/N

Special Studies

• Absorption Distribution Metabolism Excretion (Gavage)  (S0009)  Completed 
  • Citation: Morgan DL, Dunnick JK, Goehl T, Jokinen MP, Matthews HB, Zeiger E, and Mennear JH. Summary of the National Toxicology Program benzidine dye initiative. Environ Health Perspect. 1994 Jun; 102(Suppl 2): 63–78.Pubmed Abstract
  • Male Rats: F344/N; Dogs

Genetic Toxicology

• Chromosome Aberrations  (758694)  Completed 
  • Mice
  •  Positive 
• In Vitro Cytogenetics (CA/SCE)  (445801)  Completed 
  • Sister Chromatid Exchange Positive 
  • Chromosome Aberrations Positive 
• Micronucleus  (374298)  Completed 
  •  Positive 
• Mouse Lymphoma  (011624)  Completed 
  • Citation: Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
  • Mice
• Mouse Lymphoma  (018793)  Completed 
  • Citation: Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
  • Mice
• Salmonella  (689954)  Completed 
  • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
  •  Positive 
• Sister Chromatid Exchanges  (758694)  Completed 
  • Mice
  • Sister Chromatid  Positive