Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Isophorone diisocyanate M20231

 

CASRN: 4098-71-9

Formula: C12-H18-N2-O2

Synonyms/Common Names

  • Cyclohexane, 5-isocyanato-1-(isocyanatomethyl)-1,3,3-trimethyl- (9CI)
  • Isocyanic acid
  • Methylene(3,5,5-trimethyl-3,1-cyclohexylene)ester

Genetic Toxicology

  • Salmonella  (225422)  Completed 
    • Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
    •  Negative 

Organ Systems Toxicity

  • 5 days Immunotoxicity (Topical Application)  (IMM90001)  Completed 
    • Female Mice: B6C3F1
    • Mice Female Positive 
    • Dose: 0, 0.1, 0.3, OR 1.0% TREATMENT AND 3.0% CHALLENGE.
  • Immunotoxicity (Topical Application)  (IMM90027)  Completed 
    • Female Guinea Pigs: Hartley
    • Dose: 0, .1, .3, 1.0, 2.0%.