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Testing Status of Tris(Chloropropyl) Phosphate (TCPP) M20263

 

CASRN: 13674-84-5

Formula: C9-H18-Cl3-O4-P

Synonyms/Common Names

  • 2-Propanol, 1-chloro-, phosphate (3:1) (9CI)
  • TCPP
  • Tris(2-chloroisopropyl)phosphate

Short-Term Toxicity

  • 5 days (Gavage)  (C20263)  Completed 
    • 5-Day Transcriptomic Dose-Response Studies
    • Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 18.75, 37.5, 75, 150, 300, 600, 1000, or 2000 mg/kg; N=4.
  • 90 days (Dosed-Feed)  (C20712)  Report in Preparation 
    • Manuscript
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 2500, 5000, 10000, 20000, or 40000 ppm (perinatal only); Mice: 0, 1250, 2500, 5000, 10000, or 20000 ppm; 10/sex/species/dose.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20712)  Report in Preparation 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1
    • Dose: Rats: 0, 2500, 5000, 10,000 or 20,000 ppm; Male mice: 0, 1250, 2500, or 5000 ppm; Female mice: 0, 2500, 5000 or 10,000 ppm; 50/sex/species/group.

Special Studies

  • 14 days Palatability (Dosed-Feed)  (K20263B)  Completed 
    • Male and Female Rats: Wistar Han; Male and Female Mice: B6C3F1
    • Dose: 0, 30,000, 40,000, and 50,000 ppm [R,M].

Genetic Toxicology

  • Micronucleus  (G20263)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Micronucleus  (G20263B)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Negative 
  • Salmonella  (815918)  Completed 
    • Citation: Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141
    •  Negative 
  • Salmonella  (G20263C)  Completed 
    •  Negative 

Organ Systems Toxicity

  • GD 6 to GD 20 Conventional Teratology (Gavage)  (R20263B)  Completed 
    • Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of tris(chloropropyl) phosphate (CASRN 13674 84-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 01. https://doi.org/10.22427/NTP-DART-01
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 162.5, 325, or 650 mg/kg/day.
  • GD 6 to PND 127 Developmental Immunotoxicity (Dosed-Feed)  (I20263)  Data in Review 
    • Male and Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 2500, 5000, or 10000 ppm.
  • GD 6 to GD 20 Teratology Pilot Studies (Gavage)  (R20263)  Completed 
    •   (Peer Review Approval 10/18/2019A ) Citation: National Toxicology Program (NTP). 2020. NTP developmental and reproductive toxicity technical report on the prenatal development studies of tris(chloropropyl) phosphate (CASRN 13674 84-5) in Sprague Dawley (Hsd:Sprague Dawley SD) rats (gavage studies). Research Triangle Park, NC: National Toxicology Program. DART Report 01. https://doi.org/10.22427/NTP-DART-01
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 300, 650, or 1, 000 mg/kg/day.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T20263)  Completed 
    • 5-Day Transcriptomic Dose-Response Studies
    • Citation: Gwinn WM, Auerbach SS, Parham F, Stout MD, Waidyanatha S, Mutlu E, Collins B, Paules RS, Merrick BA, Ferguson S, Ramaiahgari S, Bucher JR, Sparrow B, Toy H, Gorospe J, Machesky N, Shah RR, Balik-Meisner MR, Mav D, Phadke DP, Roberts G, DeVito MJ. Evaluation of 5-day In Vivo Rat Liver and Kidney With High-throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes. Toxicol Sci. 2020 Aug 1;176(2):343-354. doi: https://doi.org/10.1093/toxsci/kfaa081.Pubmed Abstract
    • Rats: Harlan Sprague-Dawley