Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] M20287

 

CASRN: 32534-81-9

Formula: C12-H5-Br5-O

Synonyms/Common Names

  • Benzene, 1,1'-oxybis-, pentabromo deriv. (9CI)
  • DE71
  • DE 71
  • Pentabromodiphenyl oxide
  • Pentabromophenoxybenzene

Short-Term Toxicity

  • 5 days (Gavage)  (C20287D)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.076, 0.25, 0.3, 0.6, 3, 10, 20, 40, or 100 mg/kg; N=4.
  • 13 weeks (Gavage)  (C20209)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.01, 5, 50, 100, or 500 mg/kg; R: 20/sex/dose; M: 10/sex/dose.
  • GD 6 to PND 21 (Gavage)  (C20287B)  Completed 
    • Rats: Wistar Han
    • Dose: 0, 0.1, 15, or 50 mg/kg; 10/group.
  • GD 6 to PND 21 (Gavage)  (C20287C)  Completed 
    • In Utero - PND 22 Exposure to DE-71
    • Rats: Wistar Han
    • Dose: 0, 0.1, 15, or 50 mg/kg; 10/group.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20209)  Completed 
    • TR-589 (NIH Number: 16-5931)  (Peer Review Approval 06/25/2015A )
      Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: Wistar Han; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: M: 0, 3, 30, or 100 mg/kg; 50/sex/dose. R: 0, 3, 15, or 50 mg/kg; 50/sex/dose.

Special Studies

  • C. elegans  (W20287)  Completed 
    • C. elegans: N2
    • Dose: Growth:0, 0.1, 0.16, 0.25, 0.40, 0.63, 1, 1.6, 2.5, 4, 6.3, 10uMRepro:0, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100uMFeeding:0, 0.5, 0.79, 1.3, 2.0, 3.2, 5.0, 7.9, 13, 20, 32, 50uM.

Genetic Toxicology

  • Micronucleus  (A27878)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A34110)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (F34110)  Completed 
    • Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
    • Mice: B6C3F1
    • Male Negative 
    • Female NA 
  • Salmonella  (873255)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 
  • Salmonella  (A82572)  Completed 
    •  Negative 
  • Salmonella  (A83261)  Completed 
    •  Negative 

Toxicogenomics

  • 6 GD - PND 21, 2 years Microarray Analysis (Gavage)  (T20287)  Completed 
    • Rats: Wistar Han
    • Dose: Control and high dose; 5 male pups, 5 female pups, and 5 male rats/dose group.
  • Microarray Analysis (Gavage)  (T20287B)  Completed 
    • In Utero-PND 22 Exposure to DE-71
    • Rats: Wistar Han
  • 5 days Transcriptome Sequencing (Gavage)  (T20287C)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley