Testing Status of Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] M20287
CASRN: 32534-81-9
Formula: C12-H5-Br5-O
Synonyms/Common Names
- Benzene, 1,1'-oxybis-, pentabromo deriv. (9CI)
- DE71
- DE 71
- Pentabromodiphenyl oxide
- Pentabromophenoxybenzene
Short-Term Toxicity
- 5 days (Gavage)
(C20287D)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley
- Dose: Male rats: 0, 0.076, 0.25, 0.3, 0.6, 3, 10, 20, 40, or 100 mg/kg; N=4.
- 13 weeks (Gavage)
(C20209)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.01, 5, 50, 100, or 500 mg/kg; R: 20/sex/dose; M: 10/sex/dose.
- GD 6 to PND 21 (Gavage)
(C20287B)
Completed
- Rats: Wistar Han
- Dose: 0, 0.1, 15, or 50 mg/kg; 10/group.
- GD 6 to PND 21 (Gavage)
(C20287C)
Completed
- In Utero - PND 22 Exposure to DE-71
- Rats: Wistar Han
- Dose: 0, 0.1, 15, or 50 mg/kg; 10/group.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C20209)
Completed
- TR-589 (NIH Number: 16-5931)
(Peer Review Approval 06/25/2015A )
Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies) - Rats: Wistar Han; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: M: 0, 3, 30, or 100 mg/kg; 50/sex/dose. R: 0, 3, 15, or 50 mg/kg; 50/sex/dose.
- TR-589 (NIH Number: 16-5931)
(Peer Review Approval 06/25/2015A )
Special Studies
- C. elegans
(W20287)
Completed
- C. elegans: N2
- Dose: Growth:0, 0.1, 0.16, 0.25, 0.40, 0.63, 1, 1.6, 2.5, 4, 6.3, 10uMRepro:0, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100uMFeeding:0, 0.5, 0.79, 1.3, 2.0, 3.2, 5.0, 7.9, 13, 20, 32, 50uM.
Genetic Toxicology
- Micronucleus
(A27878)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Micronucleus
(A34110)
Completed
- Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
- Mice: B6C3F1
- Male Negative
- Micronucleus
(F34110)
Completed
- Citation: Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
- Mice: B6C3F1
- Male Negative
- Female NA
- Salmonella
(873255)
Completed
- Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
- Negative
- Salmonella
(A82572)
Completed
- Negative
- Salmonella
(A83261)
Completed
- Negative
Toxicogenomics
- 6 GD - PND 21, 2 years Microarray Analysis (Gavage)
(T20287)
Completed
- Rats: Wistar Han
- Dose: Control and high dose; 5 male pups, 5 female pups, and 5 male rats/dose group.
- Microarray Analysis (Gavage)
(T20287B)
Completed
- In Utero-PND 22 Exposure to DE-71
- Rats: Wistar Han
- 5 days Transcriptome Sequencing (Gavage)
(T20287C)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley