Pentabromodiphenyl ether (32534-81-9)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID2024246
Publications
TR-589
Toxicology Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] (CASRN 32534-81-9) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of a Pentabromodiphenyl Ether Mixture [DE-71 (Technical Grade)] in Wistar Han [Crl:WI(Han)] Rats and B6C3F1/N Mice (Gavage Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445
Characterization of Polybrominated Diphenyl Ether Toxicity in Wistar Han Rats and Use of Liver Microarray Data for Predicting Disease Susceptibilities
Dunnick JK, Brix A, Cunny H, Vallant M, Shockley KR.
Toxicol Pathol (2012), DOI: https://doi.org/10.1177/0192623311429973 PMID: 22267650
Toxicol Pathol (2012), DOI: https://doi.org/10.1177/0192623311429973 PMID: 22267650
Carcinogenic Activity of Pentabrominated Diphenyl Ether Mixture (DE-71) in Rats and Mice
J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, and A. Brix.
Toxicology Reports (2018) DOI: https://doi.org/10.1016/j.toxrep.2018.05.010 PMID: 29868454
Toxicology Reports (2018) DOI: https://doi.org/10.1016/j.toxrep.2018.05.010 PMID: 29868454
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes
William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005
Study Data
Toxicity and Carcinogenicity Studies
5-Day Evaluation of the Toxicity (C20287D) of Pentabromodiphenyl Ether Mixture (DE-71) (32534-81-9) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
- I01 - Animal Removal Summary (40 kB)
- I03 - Growth Curve (321 kB)
- I03C - Growth Curve (328 kB)
- I04 - Mean Body Weight Summary (69 kB)
- I04G - Mean Body Weight Gain (56 kB)
- I05 - Clinical Observations Summary (93 kB)
- PA06 - Organ Weights Summary (58 kB)
Individual Animal Data
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in F344/N Rats Exposed via Gavage
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E12 - Animal History
Individual Animal Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in F344/N Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (374 kB)
- E04 - Mean Body Weights and Survival Table (61 kB)
- E05 - Clinical Observations Summary (59 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (102 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (39 kB)
- P04 - Neoplasms by Individual Animal (223 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (39 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (235 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (164 kB)
- P14 - Individual Animal Pathology Data (204 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (40 kB)
- P40 - Survival Curves (387 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (37 kB)
- Female Individual Animal Clinical Observations (11 kB)
- Female Individual Animal Non Neoplastic Pathology Data (42 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (37 kB)
- Male Individual Animal Clinical Observations (3 kB)
- Male Individual Animal Non Neoplastic Pathology Data (43 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (362 kB)
- E04 - Mean Body Weights and Survival Table (195 kB)
- E05 - Clinical Observations Summary (44 kB)
- P02 - Incidence Rates of Neoplasms by Anatomic Site (121 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (108 kB)
- P04 - Neoplasms by Individual Animal (2 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (133 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (2 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (400 kB)
- P14 - Individual Animal Pathology Data (410 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (157 kB)
- P40 - Survival Curves (381 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (35 kB)
- Female Individual Animal Clinical Observations (6 kB)
- Female Individual Animal Non Neoplastic Pathology Data (26 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (36 kB)
- Male Individual Animal Clinical Observations (3 kB)
- Male Individual Animal Non Neoplastic Pathology Data (34 kB)
- Male Individual Animal Organ Weight Data (18 kB)
- Male Individual Animal Survival Data (11 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in Wistar Han Rats Exposed via Gavage
Study Tables
- E03 - Growth Curves (79 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (22 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (75 kB)
- P04 - Neoplasms by Individual Animal (656 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Additional Grouping of Primary Liver Tumors (22 kB)
- P08 - Statistical Analysis of Primary Tumors (278 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (952 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (560 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (608 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (78 kB)
- P40 - Survival Curves (64 kB)
Interim of Chronic Study at 3-Months
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (31 kB)
- P04 - Neoplasms by Individual Animal (117 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (32 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (125 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (114 kB)
- P14 - Individual Animal Pathology Data (89 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (32 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (424 kB)
- Female Individual Animal Clinical Observations (96 kB)
- Female Individual Animal Neoplastic Pathology Data (115 kB)
- Female Individual Animal Non Neoplastic Pathology Data (913 kB)
- Female Individual Animal Organ Weight Data (62 kB)
- Female Individual Animal Survival Data (37 kB)
- Male Individual Animal Body Weight Data (435 kB)
- Male Individual Animal Clinical Observations (93 kB)
- Male Individual Animal Neoplastic Pathology Data (107 kB)
- Male Individual Animal Non Neoplastic Pathology Data (900 kB)
- Male Individual Animal Organ Weight Data (62 kB)
- Male Individual Animal Survival Data (37 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20209) of Pentabromodiphenyl Ether (Technical) (DE 71) (32534-81-9) in B6C3F1 Mice Exposed via Gavage
Study Tables
- E03 - Growth Curves (70 kB)
- E04 - Mean Body Weights and Survival Table (29 kB)
- E05 - Clinical Observations Summary (29 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (80 kB)
- P04 - Neoplasms by Individual Animal (699 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Site (Systemic Lesions Abridged) (51 kB)
- P08 - Statistical Analysis of Primary Tumors (182 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (716 kB)
- P11 - Statistical Analysis of Survival Data (32 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (593 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (83 kB)
- P40 - Survival Curves (69 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (374 kB)
- Female Individual Animal Clinical Observations (380 kB)
- Female Individual Animal Neoplastic Pathology Data (137 kB)
- Female Individual Animal Non Neoplastic Pathology Data (1 mB)
- Female Individual Animal Survival Data (34 kB)
- Female Individual Animal Terminal Body Weight Data (57 kB)
- Male Individual Animal Body Weight Data (404 kB)
- Male Individual Animal Clinical Observations (295 kB)
- Male Individual Animal Neoplastic Pathology Data (146 kB)
- Male Individual Animal Non Neoplastic Pathology Data (1 mB)
- Male Individual Animal Survival Data (34 kB)
- Male Individual Animal Terminal Body Weight Data (57 kB)