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Testing Status of 1,2-Bis(2,4,6-tribromophenoxy)ethane M20292

 

CASRN: 37853-59-1

Formula: C14-H8-Br6-O2

Synonyms/Common Names

  • Benzene, 1,1'-(1,2-ethanediylbis(oxy))bis(2,4,6-tribromo- (9CI)
  • 1,2-Bis(2,4,6-tribromophenoxy)ethane
  • BTBPE
  • Firemaster 680
  • Flame Retardant 2

Short-Term Toxicity

  • 5 days (Gavage)  (C20292)  Report in Preparation 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.

Special Studies

  • Absorption Distribution Metabolism Excretion (Dosed-Feed)  (S0141)  Completed 
    • Citation: Nomeir AA, Markham PM, Ghanayem BI, Chadwick M. Disposition of the flame retardant 1,2-bis(2,4,6-tribromophenoxy)ethane in rats following administration in the diet. Drug Metab Dispos. 1993 Mar-Apr;21(2):209-14.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: 0.05, 0.5, 5% in Feed.

Genetic Toxicology

  • 4 hours Comet Assay (in-vitro)  (G20292)  On Test 
    • Human (Cell Lines)
  • 24 hours Comet Assay (in-vitro)  (G20292B)  On Test 
    • Human (Cell Lines)
  • Salmonella  (068726)  Completed 
    • Citation: Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
    •  Negative 

Organ Systems Toxicity

  • Neurotoxicology Assessment (Dosed-Feed)  (NTA94037)  Completed 
    • Citation: Animal Neurobehavioral Test Battery in NTP Assessment In: Advances in Neurobehavioral Toxicology: Applications in Environmental & Occupational Health (Barry L. Johnson, ED.), Lewis Publishers, Inc. pp. 403-418 (1990).
    • Male and Female Rats/Mice: F344/N

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T20292)  Report in Preparation 
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Comparative toxicity and liver transcriptomics of legacy and emerging brominated flame retardants following 5-day exposure in the rat. Toxicol Lett. 2020 Oct 10;332:222-234. doi: 10.1016/j.toxlet.2020.07.016. Epub 2020 Jul 15.Pubmed Abstract
    • Citation: Shockley KR, Cora MC, Malarkey DE, Jackson-Humbles D, Vallant M, Collins BJ, Mutlu E, Robinson VG, Waidyanatha S, Zmarowski A, Machesky N, Richey J, Harbo S, Cheng E, Patton K, Sparrow B, Dunnick JK. Transcriptomic data from the rat liver after five days of exposure to legacy or emerging brominated flame retardants. Data Brief. 2020 Aug 5;32:106136. doi: https://doi.org/10.1016/j.dib.2020.106136.Pubmed Abstract
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.