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Testing Status of Butyl Paraben M88007

 

CASRN: 94-26-8

Formula: C11-H14-O3

Synonyms/Common Names

  • Butylparaben
  • Butyl paraben
  • n-Butyl-p-hydroxybenzoate

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (K88007)  Completed 
    • Citation: Mathews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S. Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica. 2013 Feb;43(2):169-81. doi: 10.3109/00498254.2012.702935. Epub 2012 Jul 25.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male Rats: Harlan Sprague-Dawley
    • Dose: gavage; 0, 10, 100, 1000 mg/kg. intravenous; 10 mg/kg. topical application; 100, 10 mg/kg.

Genetic Toxicology

  • Salmonella  (926250)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Maternal Transfer (Dosed-Feed)  (R88007C)  Completed 
    • Citation: Roberts GK, Waidyanatha S, Kissling G, Fletcher BL, Silinski MAR, Fennell TR, Cunny HC, Robinson VG, Blystone CR. Exposure to Butyl Paraben during Gestation and Lactation in Harlan Sprague Dawley Rats via Dosed Feed. Toxicology Reports. 2016 Sep;3:774-783
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1500, 5000, or 15000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007B)  Completed 
    • RACB Main study
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 15000, or 40000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007)  Data in Review 
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10000, 20000, or 40000 ppm.