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Testing Status of Butyl Paraben M88007

 

CASRN: 94-26-8

Formula: C11-H14-O3

Synonyms/Common Names

  • Butylparaben
  • Butyl paraben
  • n-Butyl-p-hydroxybenzoate

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous)  (K88007)  Completed 
    • Citation: Mathews JM, Brown SS, Patel PR, Black SR, Banks TT, Etheridge AS, Fennell TR, Snyder RW, Blystone CR, Waidyanatha S. Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application. Xenobiotica. 2013 Feb;43(2):169-81. doi: 10.3109/00498254.2012.702935. Epub 2012 Jul 25.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male Rats: Harlan Sprague-Dawley
    • Dose: 0, 10, 100, 1000 mg/kg. 10 mg/kg. 100, 10 mg/kg.

Genetic Toxicology

  • Salmonella  (926250)  Completed 
    •  Negative 

Organ Systems Toxicity

  • Continuous Breeding (Dosed-Feed)  (R88007)  Completed 
    • Citation: Hubbard TD, Brix A, Blystone CR, McIntyre BS, Shockley K, Cunny H, Waidyanatha S, Turner KJ, McBride S, Roberts GK. Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure. Reprod Toxicol. 2020 Jul 20;96:258-272. doi: https://doi.org/10.1016/j.reprotox.2020.07.006. Epub ahead of print.
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10000, 20000, or 40000 ppm.
  • Continuous Breeding (Dosed-Feed)  (R88007B)  Completed 
    • RACB Main study
    • Citation: Hubbard TD, Brix A, Blystone CR, McIntyre BS, Shockley K, Cunny H, Waidyanatha S, Turner KJ, McBride S, Roberts GK. Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure. Reprod Toxicol. 2020 Jul 20;96:258-272. doi: https://doi.org/10.1016/j.reprotox.2020.07.006. Epub ahead of print.
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 15000, or 40000 ppm.
  • Maternal Transfer (Dosed-Feed)  (R88007C)  Completed 
    • Citation: Hubbard TD, Brix A, Blystone CR, McIntyre BS, Shockley K, Cunny H, Waidyanatha S, Turner KJ, McBride S, Roberts GK. Butylparaben multigenerational reproductive assessment by continuous breeding in Hsd:Sprague Dawley SD rats following dietary exposure. Reprod Toxicol. 2020 Jul 20;96:258-272. doi: https://doi.org/10.1016/j.reprotox.2020.07.006. Epub ahead of print.
    • Citation: Roberts GK, Waidyanatha S, Kissling G, Fletcher BL, Silinski MAR, Fennell TR, Cunny HC, Robinson VG, Blystone CR. Exposure to Butyl Paraben during Gestation and Lactation in Harlan Sprague Dawley Rats via Dosed Feed. Toxicology Reports. 2016 Sep;3:774-783
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 1500, 5000, or 15000 ppm.