Testing Status of Isobutene M88113
CASRN: 115-11-7
Formula: C4-H8
Synonyms/Common Names
- 2-Methyl-1-propene
Short-Term Toxicity
- 2 weeks (Inhalation)
(C88070)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: 4-DAY EXPOSURE, MAINTAIN ANIMALS FOR 1 WEEK FOLLOWING EXPOSURE. 0, 500, 1000, 2000, 4000, OR 8000 PPM (10/SEX/SPECIES/GROUP) 11 DAYS.
- 13 weeks (Inhalation)
(C88070)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 500, 1000, 2000, 4000, OR 8000 PPM (10/SEX/SPECIES/GROUP).
Long-Term Carcinogenicity
- 2 years (Inhalation)
(C88070)
Completed
- TR-487 (NIH Number: 99-3977)
(Peer Review Approval 12/10/1997A )
Toxicology and Carcinogenesis Studies of Isobutene in F344/N Rats and B6C3F1 Mice (Inhalation Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP).
- TR-487 (NIH Number: 99-3977)
(Peer Review Approval 12/10/1997A )
Special Studies
- Absorption Distribution Metabolism Excretion (Inhalation)
(S0137)
Completed
- Citation: Henderson RF, Sabourin PJ, Bechtold WE, Steinberg B, Chang IY. Disposition of inhaled isobutene in F344/N rats. Toxicol Appl Pharmacol. 1993 Nov;123(1):50-61. Erratum in: Toxicol Appl Pharmacol 1994 Apr;125(2):333.Pubmed Abstract
- Male Rats: F344/N
- Dose: 4, 40, 400 PPM.
Genetic Toxicology
- Micronucleus
(A91962)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(295184)
Completed
- Negative