Testing Status of Isobutene M88113

CASRN: 115-11-7

Formula: C4-H8

Synonyms/Common Names

• 2-Methyl-1-propene

Short-Term Toxicity

• 2 weeks (Inhalation)  (C88070)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: 4-DAY EXPOSURE, MAINTAIN ANIMALS FOR 1 WEEK FOLLOWING EXPOSURE. 0, 500, 1000, 2000, 4000, OR 8000 PPM (10/SEX/SPECIES/GROUP) 11 DAYS.
• 13 weeks (Inhalation)  (C88070)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 500, 1000, 2000, 4000, OR 8000 PPM (10/SEX/SPECIES/GROUP).

Long-Term Carcinogenicity

• 2 years (Inhalation)  (C88070)  Completed 
  • TR-487 (NIH Number: 99-3977)  (Peer Review Approval 12/10/1997A )
    Toxicology and Carcinogenesis Studies of Isobutene in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Some Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice No Evidence 
  • Dose: R&M: 0, 500, 2000, OR 8000 PPM (50/SEX/SPECIES/GROUP).

Special Studies

• Absorption Disposition Metabolism Elimination (Inhalation)  (S0137)  Completed 
  • Citation: Henderson RF, Sabourin PJ, Bechtold WE, Steinberg B, Chang IY. Disposition of inhaled isobutene in F344/N rats. Toxicol Appl Pharmacol. 1993 Nov;123(1):50-61. Erratum in: Toxicol Appl Pharmacol 1994 Apr;125(2):333.Pubmed Abstract
  • Male Rats: F344/N
  • Dose: 4, 40, 400 PPM.

Genetic Toxicology

• Micronucleus  (A91962)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (295184)  Completed 
  •  Negative