Testing Status of trans-Cinnamaldehyde M88146
CASRN: 14371-10-9
Related: CINNAMALDEHYDE (104-55-2)
Formula: C9-H8-O
Synonyms/Common Names
- 2-Propenal, 3-phenyl-, (E)- (9CI)
Short-Term Toxicity
- 2 weeks (Gavage)
(C56111E)
Completed
- Rats: F344/N
- Dose: FEMALE RATS ONLY: 0, 235, 470, 940, 1410 MG/KG/DAY.
- 13 weeks (Microencapsulation in Feed)
(C56111B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.41, 0.82, 1.65 OR 3.30% OR 4100, 8200, 16500 OR 33000 PPM; 10/SEX/DOSE.
Long-Term Carcinogenicity
- 2 years (Microencapsulation in Feed)
(C56111B)
Completed
- TR-514 (NIH Number: 04-4448)
(Peer Review Approval 09/05/2002A )
Toxicology and Carcinogenesis Studies of trans-Cinnamaldehyde (Microencapsulated) (CASRN 14381-10-9) in F344/N Rats and B6C3F1 Mice (Feed Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: 0 (UNTREATED), 0 (VEHICLE), 1, 000, 2, 100, or 4, 100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%). R&M: 0 (UNTREATED), 0 (VEHICLE), 1, 000, 2, 100, or 4, 100 ppm; 50/SEX/DOSE (equivalent to 0.1%, 0.21%, or 0.41%).
- TR-514 (NIH Number: 04-4448)
(Peer Review Approval 09/05/2002A )
Genetic Toxicology
- Drosophila
(896321)
Completed
- Citation: Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
- Sex-Linked Recessive Lethal Positive
- Reciprocal Translocation Negative
- In Vitro Cytogenetics (CA/SCE)
(290481)
Completed
- Citation: Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Negative
- Micronucleus
(A19689)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Micronucleus
(B19689)
Completed
- Mice: B6C3F1
- Male Equivocal
- Female Negative
- Salmonella
(579971)
Completed
- Weakly Positive
- Salmonella
(816373)
Completed
- Citation: Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
- Negative