Testing Status of Trimethylolpropane triacrylate M882479

CASRN: 15625-89-5

Formula: C15-H20-O6

Synonyms/Common Names

• Acrylic acid, triester with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol
• 2-ETAC
• 2-Ethyl-2-(hydroxymethyl)-1,3-propanediol triacrylate
• 2-Ethyl-2-(((2-oxo-2-propenyl)oxy)methyl)-1,3-propanediyl ester (9CI)
• TMPTA

Short-Term Toxicity

• 2 weeks (Topical Application)  (C88133)  Completed 
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/KG.
• 13 weeks (Topical Application)  (C88133)  Completed 
  • GMM-03 (NIH Number: 06-4450)  (Peer Review Approval 09/06/2002A )
    Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Dose: R&M: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 10/SEX/SPECIES/DOSE.
• 26 weeks (Topical Application)  (C88133B)  Completed 
  • GMM-03 (NIH Number: 06-4450)  (Peer Review Approval 09/06/2002A )
    Toxicology Studies of Trimethylolpropane Triacrylate (Technical Grade) (CASRN 15625-89-5) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal Studies)
  • Mice: Tg.AC (FVB/N) Hemizygous
  • Dose: 0, 0.75, 1.5, 3, 6, OR 12 MG/KG; 15/SEX.

Long-Term Carcinogenicity

• 2 years (Topical Application)  (C88133C)  Completed 
  • TR-576 (NIH Number: 12-5918)  (Peer Review Approval 02/08/2012A )
    Toxicology and Carcinogenesis Studies of Trimethylolpropane triacrylate (Technical Grade) in F344/N Rats (Topical Application Studies)
  • Rats: F344/N; Mice: B6C3F1
  • Carcinogenesis Results
    • Male Rats Equivocal Evidence 
    • Female Rats No Evidence 
    • Male Mice No Evidence 
    • Female Mice Some Evidence 
  • Dose: R&M: 0, 0.3, 1.0, OR 3.0 MG/KG; 65/SEX/SPECIES/DOSE.

Special Studies

• Absorption Distribution Metabolism Excretion (Intravenous; Topical Application; Intravenous; Topical Application)  (S0547)  Completed 
  • Male Rats: F344/N; Male Mice: B6C3F1
  • Dose: IV: RAT 10 MG/KG MOUSE ??; DERMAL: RAT 1.5, 15, 150 MG/KG, MOUSE 1.2 MG/KG.

Genetic Toxicology

• Micronucleus  (A10307)  Completed 
  • Mice: Tg.AC
  • Male Negative 
  • Female Negative 
• Micronucleus  (A71420)  Completed 
  • Mice: B6C3F1
  • Male Negative 
  • Female Negative 
• Salmonella  (A46551)  Completed 
  •  Negative 

Organ Systems Toxicity

• 4 days Immunotoxicity (Topical Application)  (IMM95008)  Completed 
  • Female Mice: B6C3F1
  • Dose: MEST: 0.01, 0.03, 0.1 & 0.3% IN 99.8% ACETONE AND 1.0% FOR CHALLENGE LLNA: 0.03, 0.1, 0.15, 0.3 AND 1.0 FOR SENSITIZATION (0.25% DNFB POSITIVE CONTROL AND 0.5 OR 0.25% FOR CHALLENGE).
• Immunotoxicity (Topical Application)  (IMM97003)  Completed 
  • Female Mice: BALB/c
  • Dose: 0.01, 0.05 AND 0.1% IN ACETONE FOR SENSITIZATION, AND 0.25% FOR CHALLENGE IN THE MEST AND 0.05, 0.01, AND 0.25% FOR SENSITIZATION IN THE LLNA.
• Teratology Pilot Studies (Gavage)  (TRP92051)  Completed 
  • Rats
  • Dose: 0, 100, 500, 1000, 2000, 3000 MG/KG/DAY.
• Teratology Pilot Studies (Gavage)  (TRP92052)  Completed 
  • Rabbits: New Zealand White
  • Dose: 0, 50, 250, 1000, 1500, 2000 MG/KG/DAY.

in vitro Testing

• Bovine Corneal Opacity and Premeability Assay  (IVT20001A)  Completed 
• Dose-Response Cytotoxicity Assay Using the EpiDermTM Skin Model  (IVT20001B)  Completed 
• Neutral Red Uptake Bioassay  (IVT20001C)  Completed 
• Cytotoxicity Assay Using MTT Reduction in Primary Rat Hepatocytes  (IVT20001D)  Completed