Testing Status of 3,3',4,4'-Tetrachloroazobenzene M882486
CASRN: 14047-09-7
Related: 3,3',4,4'-TETRACHLOROAZOXYBENZENE
Formula: C12-H6-Cl4-N2
Synonyms/Common Names
- Diazene, bis(3,4-dichlorophenyl)- (9CI)
- TCAB
Short-Term Toxicity
- 18 days (Gavage)
(C29323)
Completed
- Pilot neurobehavioral study
- Rats: Sprague Dawley
- Dose: 0, 1.0, 3.0, OR 10.0 MG/KG/DAY THROUGH PND 4-21/3 LITTERS PER GROUP.
- 2 weeks (Gavage)
(C88148)
Completed
- TOX-65 (NIH Number: 99-3945)
Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene Administered by Gavage to F344/N Rats and B6C3F1 Mice (CASRN 14047-09-7) - Rats: F344/N; Mice: B6C3F1
- Dose: R: 12.5, 32, 80, 200 OR 500 MG/KG BODY WEIGHT DAY; M: 1, 3.2, 10, 32 OR 100 MG/KG BODY WEIGHT DAY PLUS CONTROLS (M&F; 5/GROUP).
- TOX-65 (NIH Number: 99-3945)
- 5 days (Gavage)
(C88486)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley
- Dose: Female rats: 0, 0.1, 0.3, 1, 3, 10, 30, 100, 200, or 400 mg/kg; N=4. Male rats: 0, 0.1, 0.3, 1, 3, 10, 30, 100, 200, or 400 mg/kg; N=4.
- 5 weeks (Gavage)
(C29323)
Completed
- Developmental toxicity
- Rats: Sprague Dawley
- Dose: FEMALE RATS: 0, 1.0, 3.0, OR 10 MG/KG/DAY/30 PER GROUP (PREBREED); 25 PER GROUP (TIMED-MATED).
- 13 weeks (Gavage)
(C88148)
Completed
- TOX-65 (NIH Number: 99-3945)
(Tox Peer Review 06/18/1998A )
Toxicity Studies of 3,3',4,4'-Tetrachloroazobenzene Administered by Gavage to F344/N Rats and B6C3F1 Mice (CASRN 14047-09-7) - Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.1, 1.0, 3.0, 10, OR 30 MG/KG BODY WEIGHT (M&F; 10/GROUP).
- TOX-65 (NIH Number: 99-3945)
(Tox Peer Review 06/18/1998A )
- 13 weeks (Gavage)
(C88148B)
Completed
- Rats: Harlan Sprague-Dawley
- Dose: 0, .1, .3, 1, 10, 30, OR 100 MG/KG; 10/SEX/DOSE.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C88148C)
Completed
- TR-558 (NIH Number: 11-5899)
(Peer Review Approval 02/25/2009A )
Toxicology and Carcinogenesis Studies of 3,3',4,4'-Tetrachloroazobenzene (CASRN 14047-09-7) in Harlan Sprague-Dawley Rats and B6C3F1 Mice (Gavage Studies) - Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: R: 0, 10, 30, OR 100 MG/KG AND M: 0, 3, 10, OR 30 MG/KG; 50/SEX/SPECIES/DOSE.
- TR-558 (NIH Number: 11-5899)
(Peer Review Approval 02/25/2009A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage)
(S0295)
Completed
- Male Rats: F344/N
- Dose: 320, 32, 3.2 MG/KG.
- Metabolism (Gavage)
(S0596)
Completed
- Citation: Pillai UA, Ziegler TL, Wang DX, Kattnig MJ, McClure T, Liebler DC, Mayersohn M, Sipes IG. 3,3',4,4'-tetrachloroazobenzene absorption, disposition, and metabolism in male Fischer 344 rats. Drug Metab Dispos. 1996 Feb;24(2):238-44.Pubmed Abstract
- Rats: F344/N
- Toxicokinetic Study (Gavage)
(S0665)
Completed
- Female Rats: SPRAGUE DAWL
Genetic Toxicology
- Micronucleus
(A43252)
Completed
- Citation: Witt, K.L., Zeiger, E., Tice, R.R., and van Birgelen, A.P.J.M. The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results. Mutation Res. Vol. 472 (2000) 147-154
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A95885)
Completed
- Citation: Witt, K.L., Zeiger, E., Tice, R.R., and van Birgelen, A.P.J.M. The genetic toxicity of 3,3',4,4'-tetrachloroazobenzene and 3,3',4,4'-tetrachloroazoxybenzene: discordance between acute mouse bone marrow and subchronic mouse peripheral blood micronucleus test results. Mutation Res. Vol. 472 (2000) 147-154
- Mice: B6C3F1
- Male Positive
- Female Positive
- Salmonella
(A17768)
Completed
- Negative
- Salmonella
(A30420)
Completed
- Negative
- Salmonella
(A71232)
Completed
- Positive
Organ Systems Toxicity
- 1st generation Continuous Breeding (Legacy) (Gavage)
(RACB20101)
Completed
- Male and Female Rats: Sprague Dawley
- Dose: 0, 0.1, 1, 3, OR 10 MG/KG.
- approximately 36 days Conventional Teratology (Gavage)
(R88486)
Completed
- Female Rats: Crl:CD (SD)
- Dose: 0 or 10 mg/kg/day.
- Neurobehavioral & immunologic function assessment; F0 (~54 days); F1 male (18 days); F1 female (39 days) Developmental Toxicity (Gavage)
(R88486B)
Completed
- Neurobehavioral & immunologic function
- Male and Female Rats: Crl:CD (SD)
- Dose: 0, 0.1, 1, or 10 mg/kg/day.
- 28 days Immunotoxicity (Gavage)
(I88486)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 0.1, 0.5, 1, 5, or 10 mg/kg/day.
- 28 days Immunotoxicity (Gavage)
(I88486B)
Completed
- Female Rats: Crl:CD (SD)
- Dose: 0, 0.1, 1 or 10 mg/kg/day.
Toxicogenomics
- 5 days Transcriptome Sequencing (Gavage)
(T88486)
On Test
- 5-Day Transcriptome Dose-Response Study
- Rats: Harlan Sprague-Dawley