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Testing Status of 3'-Azido-3'-deoxythymidine and 2',3'-Dideoxycytidine M890013

 

CASRN: AZTDDCCOMB

Formula: C10-H13-N5-O4 C9-H13-N3-O3

Synonyms/Common Names

  • 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AIDS initiative)
  • AZT + DDC

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 7481-89-2 - 2',3'-Dideoxycytidine

Short-Term Toxicity

  • 4 weeks (Gavage)  (C89007)  Completed 
    • Mice: B6C3F1
    • Dose: M: VARIOUS COMBINATIONS OF AZT 0, 500, OR 1000 MG/KG/DAY WITH DDC 0, 10, 100, 500, OR 1000 MG/KG/DAY.

Genetic Toxicology

  • Micronucleus  (848765)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Micronucleus  (A72656)  Completed 
    • Mice: Swiss CD-1
    • Male Positive 

Organ Systems Toxicity

  • 1 to 31 Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB93149)  Completed 
    • Male and Female Mice: Swiss
    • Dose: N/A; N/A; N/A; N/A.
  • 6 to 15 GD Conventional Teratology (Gavage)  (TER97001)  Completed 
    • Female Mice: Swiss CD-1
    • Dose: AZT -- 0, 100, 200, OR 400 MG/KG/DAY AND DDC -- 0, 200, OR 500 MG/KG/DAY.