Testing Status of Methylene blue trihydrate M90016
CASRN: 7220-79-3
Formula: C16-H18-N3-S.Cl.3H2-O
Synonyms/Common Names
- C.I. Basic Blue 9, trihydrate
- Phenothiazin-5-ium, 3,7-bis(dimethylamino)-, chloride, trihydrate
Short-Term Toxicity
- 4 weeks (Gavage)
(C91005)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 MG/KG BODY WT. R: 20/GROUP/SEX; M: 10/GROUP/SEX. R&M: 0, 125, 250, 500, 1000 or 2000 mg/kg 10/Group/Sex (10 core/10 clinical pathology).
- 13 weeks (Gavage)
(C91005B)
Completed
- Rats: F344/N; Mice: B6C3F1
- Dose: R&M: 0, 25, 50, 100, OR 200 MG/KG; 30 SEX/SPECIES/GROUP.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C91005C)
Completed
- TR-540 (NIH Number: 08-4429)
(Peer Review Approval 06/12/2006A )
Toxicology and Carcinogenesis Studies of Methylene Blue Trihydrate (CASRN 7220-79-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1
- Carcinogenesis Results
- Male Rats Some Evidence
- Female Rats No Evidence
- Male Mice Some Evidence
- Female Mice Equivocal Evidence
- Dose: R: 0, 5, 25, OR 50 MG/KG; M: 0, 2.5, 12.5, OR 25 MG/KG; 50/SEX/SPECIES.
- TR-540 (NIH Number: 08-4429)
(Peer Review Approval 06/12/2006A )
Special Studies
- Preliminary Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)
(S0660)
Completed
- Preliminary Toxicokinetic Study
- Rats: F344/N; Male and Female Mice: B6C3F1; Mice: B6C3F1
- Dose: IV: 0.625 mg/ml (rats, 2 ml/kg); 0.125 mg/ml (mice, 4 ml/kg).
Genetic Toxicology
- In Vitro Cytogenetics (CA/SCE)
(563848)
Completed
- Sister Chromatid Exchange Positive
- Chromosome Aberrations Positive
- Micronucleus
(A76244)
Completed
- Mice: B6C3F1
- Male Negative
- Micronucleus
(A77225)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(811345)
Completed
- Positive
- Salmonella
(A35880)
Completed
- Positive
Organ Systems Toxicity
- Conventional Teratology (Gavage)
(TER92124)
Completed
- Rats: Sprague Dawley
- Rats Maternal Positive
- Rats Fetal Positive
- Dose: REP I: 0, 50, 200, 350 MG/KG/DAY REP II: 0, 50, 125, 200 MG/KG/DAY.
- 6 to 19 GD Conventional Teratology (Gavage)
(TER92125)
Completed
- Female Rabbits: New Zealand White
- Rabbits Maternal Positive
- Rabbits Fetal Positive
- Dose: 0, 50, 100, 150 MG/KG/DAY.
- 6 to 15 GD Teratology Pilot Studies (Gavage)
(TRP91018)
Completed
- Female Rats: Sprague Dawley
- Dose: 0, 50, 100, 200, 400, OR 600 MG/KG.
- 6 to 19 GD Teratology Pilot Studies (Gavage)
(TRP91019)
Completed
- Female Rabbits: New Zealand White
- Dose: 0, 10, 50, 100, 200, OR 300 MG/KG.