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Testing Status of Perfluorooctanoic acid (PFOA) M910070

 

CASRN: 335-67-1

Formula: C8-H-F15-O2

Synonyms/Common Names

  • C8 Carboxylic acid
  • Pentadecafluorooctanoic acid (9CI)
  • PFOA

Short-Term Toxicity

  • 28 days (Gavage)  (C91070B)  Completed 
    • TOX-97 
      Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: Males: 0, 0.625, 1.25, 2.5, 5, or 10 mg/kg; Females: 0, 6.25, 12.5, 25, 50, or 100 mg/kg.
  • 5 days (Gavage)  (C91070C)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 0.156, 0.3125, 0.625, 1.25, 2.5, 5, 10, or 20 mg/kg; N=4.
  • 4 days (Gavage)  (C91070)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: Male mice: 0, 15, 180 mg/kg/day.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20614B)  Report in Preparation 
    • TR-598
      Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: MR: 0, 20, 40, 80, 300/0, 300/20, 300/40, or 300/80 ppm.
  • 2 years (Dosed-Feed)  (C20614)  Report in Preparation 
    • TR-598
      Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid (CASRN 335-67-1) Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley® SD®) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: FR: 0/0, 0/300, 0/1000, 150/300, or 300/1000 ppm; MR: 0/0, 0/150, 0/300, 150/150, or 300/300; 60/sex.

Modified One-Generation

  • Dose Range Finding (Gavage)  (MOG91070)  Completed 
    • Dose Range Finding
    • Rats: Harlan Sprague-Dawley; Mice: CD-1 Reg.[Crl:CD1(ICR)]
    • Dose: R: 0, 6.25, 12.5, 25, or 50 mg/kg.

Special Studies

  • Cell Proliferation (Gavage)  (S0174)  Completed 
    • Citation: Thottassery J, Winberg L, Youssef J, Cunningham M, Badr M. Regulation of perfluorooctanoic acid-induced peroxisomal enzyme activities and hepatocellular growth by adrenal hormones. Hepatology. 1992 Feb;15(2):316-22.Pubmed Abstract
    • Male Rats: Sprague Dawley
    • Dose: 150 MG/KG.
  • Toxicokinetic Study (Gavage; Intravenous)  (K10075)  Completed 
    • Citation: Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Gibbs ST, Granville CA, Blystone CR. Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration. Xenobiotica. 2019 Nov. DOI: 10.1080/00498254.2019.168376.Pubmed Abstract
    • Male and Female Rats: Hsd:Sprague Dawley SD

Genetic Toxicology

  • 4 days Comet Assay (Gavage)  (G91070B)  Completed 
    • Rats: Sprague Dawley
  • Micronucleus  (G91070)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Positive 
    • Female Negative 
  • Salmonella  (A98283)  Completed 
    •  Equivocal 

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (T91070B)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
  • 4 days Microarray Analysis (Gavage)  (T91070)  Completed 
    • Liver Targeted Testing study of Toxcast Chemicals
    • Rats: Harlan Sprague-Dawley
    • Dose: 180 mg/kg; 6 rats.