Testing Status of 2,3,4,7,8-Pentachlorodibenzofuran M920005

Absorption Distribution Metabolism Excretion (Intravenous; Topical Application) (S0518) Completed
- Citation: Brewster DW, Elwell MR, Birnbaum LS. Toxicity and disposition of 2,3,4,7,8-pentachlorodibenzofuran (4PeCDF) in the rhesus monkey (Macaca mulatta). Toxicol Appl Pharmacol. 1988 Apr;93(2):231-46.Pubmed Abstract
- Monkeys: Rhesus
- Dose: 34 ug/kg.
Absorption Distribution Metabolism Excretion (Gavage; Inhalation) (S0519) Completed
- Citation: Brewster DW, Birnbaum LS. Disposition and excretion of 2,3,4,7,8-pentachlorodibenzofuran in the rat. Toxicol Appl Pharmacol. 1987 Sep 15;90(2):243-52.Pubmed Abstract
- Male Rats: F344/N
- Dose: 34 ug/kg. 34, 170, 340 ug/kg.
Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous) (S0764) Completed
- Citation: Brewster DW, Banks YB, Clark AM, Birnbaum LS. Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and three polychlorinated dibenzofurans. Toxicol Appl Pharmacol. 1989 Jan;97(1):156-66.Pubmed Abstract
- Male Rats: F344/N
- Dose: 34, 170, 340 ug/kg.
Toxicokinetic Study (Gavage) (S0623) Completed
- Female Rats: Sprague Dawley
- Dose: 0, 10, 30, 100, 300, 1000 ng/kg, females. Male to be used as sentinels.

Conventional Teratology (Gavage) (TER86102) Completed
- Mice: C57BL/6
- Mice Maternal Positive
- Mice Fetal Positive
- Dose: 0, .001, .003, .01, .02, .03, .04, .06, .08 MG/KG.
Single dose Immunotoxicity (Gavage) (I92005) Completed
- Female Mice: B6C3F1
- Dose: 0, 3, 9, 15, 30 and 90 ug/kg.