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Testing Status of Perfluorodecanoic acid (PFDA) M920006

 

CASRN: 335-76-2

Formula: C10-H-F19-O2

Synonyms/Common Names

  • C10 Carboxylic acid
  • NDFDA
  • Nonafluorodecanoic acid
  • Nonafluror-n-decanoic acid
  • Perfluoro-n-decanoic acid
  • PFDA

Short-Term Toxicity

  • 28 days (Gavage)  (C20615)  Completed 
    • TOX-97 
      Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
    • Rats: Harlan Sprague-Dawley
    • Dose: M&F: 0, 0.156, 0.312, 0.625, 1.25, or 2.5 mg/kg.

Special Studies

  • Mechanisms  (S0688)  Completed 
    • Citation: Harris MW, Uriah LC, Birnbaum LS. Acute toxicity of perfluorodecanoic acid in C57BL/6 mice differs from 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fundam Appl Toxicol. 1989 Nov;13(4):723-36.Pubmed Abstract
    • Female Mice: C57BL/6
  • Mechanisms  (S0689)  Completed 
    • Citation: Brewster DW, Birnbaum LS. The biochemical toxicity of perfluorodecanoic acid in the mouse is different from that of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Appl Pharmacol. 1989 Jul;99(3):544-54.Pubmed Abstract
    • Female Mice: C57BL/6
  • Other  (S0775)  Completed 
    • Citation: Harris MW, Birnbaum LS. Developmental toxicity of perfluorodecanoic acid in C57BL/6N mice. Fundam Appl Toxicol. 1989 Apr;12(3):442-8.Pubmed Abstract
    • Mice: C57BL/6
  • Toxicokinetic Study (Gavage; Intravenous)  (K10214)  Completed 
    • Citation: Dzierlenga AL, Robinson VG, Waidyanatha S, DeVito MJ, Eifrid MA, Gibbs ST, Granville CA, Blystone CR. Toxicokinetics of perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA) and perfluorodecanoic acid (PFDA) in male and female Hsd:Sprague dawley SD rats following intravenous or gavage administration. Xenobiotica. 2019 Nov. DOI: 10.1080/00498254.2019.168376.Pubmed Abstract
    • Male Rats: Hsd:Sprague Dawley SD; Female Rats: Hsd:Sprague Dawley SD; Male Rats: Hsd:Sprague Dawley SD
    • Dose: 2 mg/kg. 2, 10, or 20 mg/kg.

Genetic Toxicology

  • Micronucleus  (G92006)  Completed 
    • Rats: Harlan Sprague-Dawley
    • Male Negative 
    • Female Negative 
  • Salmonella  (A10025)  Completed 
    •  Negative 

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (I92006)  Completed 
    • Citation: Frawley RP, Smith M, Cesta M, Hayes-Bouknight S, Blystone C, Kissling GE, Harris S, Germolec D. (2018) Immunotoxic and hepatotoxic effects of perfluoro-n-decanoic acid (PFDA) on female Harlan Sprague–Dawley rats and B6C3F1/N mice when administered by oral gavage for 28 days, Journal of Immunotoxicology, 15:1, 41-52, DOI: 10.1080/1547691X.2018.1445145
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 0.125, 0.25, 0.5, 1 or 2 mg/kg/day.
  • Conventional Teratology (Gavage)  (TER89103)  Completed 
    • Mice: C57BL/6
    • Mice Maternal Positive 
    • Mice Fetal Positive 
    • Dose: 0, .03, .1, .3, 1.0, 3.0, 6.4, 12.8 MG/KG/DAY.