Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of AZT + Methadone HCl (AIDS) M920012

 

CASRN: AZTMETHCOMB

Synonyms/Common Names

  • 3'-Azido-3'-deoxythymidine + Methadone Hydrochloride

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 1095-90-5 - Methadone hydrochloride

Short-Term Toxicity

  • 13 weeks (Gavage)  (C92014)  Completed 
    • Mice: B6C3F1
    • Dose: AZT: 200, 400, OR 800 MG/KG/DAY WITH METHADONE HCL: 5, 15, OR 30 MG/KG/DAY.

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0305)  Completed 
    • Female Mice: B6C3F1; Male Mice: B6C3F1; Female Mice: B6C3F1; Female Mice: Swiss CD-1
    • Dose: IV: AZT: 100 MG/KG METHADONE: 0 MG/KG & AZT: 0 MG/KG METHADONE: 2.5 ORAL: AZT: 100 METHADONE: 0 AZT: 200 METHADONE: 0 AZT: 400 METHADONE: 0 OR 15 AND AZT: 0 METHADONE: 2.5 AZT: 0 METHADONE: 7.5 AZT: 0 OR 400 METHADONE: 15 MG/KG chemtasks chem00207 & 208.

Organ Systems Toxicity

  • Repro/Dev Gen Tox (28-Day) (Gavage)  (RACB92023)  Completed 
    • Male and Female Mice: Swiss
    • Dose: AZT:0, 200, 400, 800 MG/KG/DAY; METHADONE: 0, 5, 15, 30 MG/KG/DAY.