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Testing Status of Water disinfection byproducts (Bromodichloroacetic Acid) M920032

 

CASRN: 71133-14-7

Formula: C2-H-Br-Cl2-O2

Synonyms/Common Names

  • Dichlorobromoacetic acid (Water disinfection byproducts)

Short-Term Toxicity

  • 5 days (Gavage)  (C92032)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 1.25, 2.5, 5, 10, 20, 40, 80, or 160 mg/kg; N=4.
  • 2 weeks (Dosed-Water)  (C96014)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/l; 10/sex/species.
  • 13 weeks (Dosed-Water)  (C96014)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 62.5, 125, 250, 500, or 1000 mg/l; 20/sex/species.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C96014B)  Completed 
    • TR-583 (NIH Number: 16-5925)  (Peer Review Approval 05/22/2014A )
      Toxicology Studies of Bromodichloroacetic Acid (CASRN 71133-14-7) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Bromodichloroacetic Acid in F344/NTac Rats and B6C3F1/N Mice (Drinking Water Studies)
    • Rats: F344/NTac; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Clear Evidence NONE
      • Male Mice Clear Evidence NONE
      • Female Mice Clear Evidence NONE
    • Dose: R&M: 0, 250, 500, or 1000 mg/L; 50/sex/species/dose.

Toxicogenomics

  • 5 days Transcriptome Sequencing (Gavage)  (C92032-02)  On Test 
    • Rats: Harlan Sprague-Dawley
  • 5 days Transcriptome Sequencing (Gavage)  (T92032)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley