Testing Status of Dibromoacetic acid M920037
CASRN: 631-64-1
Formula: C2-H2-Br2-O2
Synonyms/Common Names
- Acetic acid, 2,2-dibromo-
Special Studies
- Toxicokinetic Study (Gavage; Dosed-Water; Intravenous; Gavage; Dosed-Water; Intravenous)
(K04228)
Completed
- Male and Female Rats: Fischer 344; Male and Female Mice: B6C3F1
- Dose: 0.5, 2.0 mg/mL [R,M]. 25 mg/kg. 25, 50, 125 mg/kg. 70 mg/kg. 70, 125, 350 mg/kg.
- Toxicokinetic Study (Gavage; Dosed-Water; Intravenous; Gavage; Dosed-Water; Intravenous)
(K07475)
Completed
- Citation: Matthews JL, Schultz IR, Easterling MR, Melnick RL. Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats. Toxicol Appl Pharmacol. 2010 Apr 15;244(2):196-207. https://doi.org/10.1016/j.taap.2009.12.033Pubmed Abstract
- Female Rats: Fischer 344; Male Mice: B6C3F1
- Dose: 10, 100, 200 mg/kg, 2 weeks, with and without day 15 gavage challenge 10, 100, 200 mg/kg. 10, 110 mg/kg. 10, 40, 100 mg/kg. 100 mg/kg. 100, 200, 400 mg/kg. 3.4, 34.4, 68.6 mg/kg, 2 weeks, with and without day 15 gavage challenge 3.4, 34.4, 68.6 mg/kg.
Genetic Toxicology
- Micronucleus
(A03046)
Completed
- Mice: B6C3F1
- Male Positive
- Female Negative
- Salmonella
(A36379)
Completed
- Positive
Organ Systems Toxicity
- 21 days Spermiation Inhibition (Gavage)
(RACB93159)
Completed
- Male Rats: F344/N
- Dose: </= 300 MG/KG.