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Testing Status of Dibromoacetic acid M920037

 

CASRN: 631-64-1

Formula: C2-H2-Br2-O2

Synonyms/Common Names

  • Acetic acid, 2,2-dibromo-

Special Studies

  • Toxicokinetic Study (Gavage; Dosed-Water; Intravenous; Gavage; Dosed-Water; Intravenous)  (K04228)  Completed 
    • Male and Female Rats: Fischer 344; Male and Female Mice: B6C3F1
    • Dose: 0.5, 2.0 mg/mL [R,M]. 25 mg/kg. 25, 50, 125 mg/kg. 70 mg/kg. 70, 125, 350 mg/kg.
  • Toxicokinetic Study (Gavage; Dosed-Water; Intravenous; Gavage; Dosed-Water; Intravenous)  (K07475)  Completed 
    • Citation: Matthews JL, Schultz IR, Easterling MR, Melnick RL. Physiologically based pharmacokinetic modeling of dibromoacetic acid in F344 rats. Toxicol Appl Pharmacol. 2010 Apr 15;244(2):196-207. https://doi.org/10.1016/j.taap.2009.12.033Pubmed Abstract
    • Female Rats: Fischer 344; Male Mice: B6C3F1
    • Dose: 10, 100, 200 mg/kg, 2 weeks, with and without day 15 gavage challenge 10, 100, 200 mg/kg. 10, 110 mg/kg. 10, 40, 100 mg/kg. 100 mg/kg. 100, 200, 400 mg/kg. 3.4, 34.4, 68.6 mg/kg, 2 weeks, with and without day 15 gavage challenge 3.4, 34.4, 68.6 mg/kg.

Genetic Toxicology

  • Micronucleus  (A03046)  Completed 
    • Mice: B6C3F1
    • Male Positive 
    • Female Negative 
  • Salmonella  (A36379)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 21 days Spermiation Inhibition (Gavage)  (RACB93159)  Completed 
    • Male Rats: F344/N
    • Dose: </= 300 MG/KG.