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Testing Status of Cyclohexene oxide M930034

 

CASRN: 286-20-4

Formula: C6-H10-O

Synonyms/Common Names

  • Cyclohexane oxide
  • Cyclohexene epoxide
  • 1,2-Epoxycyclohexane
  • 7-Oxabicyclo(4.1.0)heptane
  • Tetramethyleneoxirane

Short-Term Toxicity

  • 4 weeks (Topical Application)  (C93012)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 3.75, 7.5, 15, 30, OR 60 MG/KG; 5/SEX/SPECIES/DOSE.
  • 4 weeks (Gavage)  (C93012B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 6.25, 12.5, 25, 50, OR 100 MG/KG; 5/SEX/SPECIES/DOSE.
  • 2 weeks (Gavage)  (C93012C)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MALE RATS AND FEMALE MICE: 0, 250, 500, 1000, 2000 MG/KG; 5/SPECIES/GROUP.

Special Studies

  • Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Gavage; Topical Application)  (S0572)  Completed 
    • Citation: Sauer JM, Bao J, Smith RL, McClure TD, Mayersohn M, Pillai U, Cunningham ML, Sipes IG. Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse. Drug Metab Dispos. 1997 Mar;25(3):371-8. Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
  • Metabolism (Gavage)  (S0802)  Completed 
    • Citation: Bao J, Smith RL, Sauer JM, Pillai U, Sipes IG. Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography. J Chromatogr B Biomed Sci Appl. 1997 Aug 15;696(1):59-68.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: (gavage) Urine samples from rats which received an oral dose (100 mg/kg) of CHO were incubated at 37 degrees C with beta-glucuronidase (2000 un-its/ml urine) type VII A from E. coli (Sigma, St. Louis, MO, USA) [R].
  • Metabolism (Gavage; Intravenous; Gavage)  (S0803)  Completed 
    • Citation: Sauer JM, Bao J, Smith RL, McClure TD, Mayersohn M, Pillai U, Cunningham ML, Sipes IG. Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse. Drug Metab Dispos. 1997 Mar;25(3):371-8.Pubmed Abstract
    • Rats: F344/N; Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: (gavage) [14C]CHO (10 and 100 mg/kg), four rats per dose and four mice per dose. All animals received ∼50 μCi/kg of the radiolabeled compound [R,M]. 50 mg/kg, 120 μCi/ml.

Genetic Toxicology

  • Micronucleus  (A13539)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (A10205)  Completed 
    •  Positive 
  • Salmonella  (A18107)  Completed 
    •  Negative 
  • Salmonella  (A61059)  Completed 
    •  Positive 
  • Salmonella  (A66013)  Completed 
    •  Positive