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Testing Status of Gemfibrozil M930066

 

CASRN: 25812-30-0

Formula: C15-H22-O3

Synonyms/Common Names

  • 5-(2,5-dimethylphenoxy)-2,2-dimethyl pentanoic acid

Special Studies

  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous; Gavage; Intravenous)  (S0541)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 15 mg/kg preliminary. 15 mg/kg single administration. 16.6 mg/kg preliminary. 8.4 mg/kg single administration. 16.6, 2124.8 mg/kg; feed 200, 16000 ppm preliminary. 8.4, 16.6, 49.8 mg/kg single administration. 30, 1000 mg/kg; feed 1500, 12000 ppm (2.1 & 107.1 mg/kg) preliminary. 8, 15, 30 mg/kg single administration. 4.29 mg/kg preliminary. 4.29 mg/kg single administration. 4.29, 685.7 mg/kg, feed 100, 16,000 ppm preliminary. 4.29, 50, 100 mg/kg single administration.
  • Toxicokinetic Study (Dosed-Feed)  (S0582)  Completed 
    • Male Rats: Sprague Dawley; Male Mice: B6C3F1; Male Hamsters: Syrian Golden
    • Dose: 10, 100, 1000, 4000 or 8000 ppm, 90d. 10, 100, 1000, 8000 or 16000 ppm, 90d. 1500, 3000, 6000, 12,000 or 24,000, 14d. 100, 1000, 6000, 12,000, 24,000 ppm, 90d.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (S0637)  Completed 
    • Citation: Dix KJ, Coleman DP, Jeffcoat AR. Comparative metabolism and disposition of gemfibrozil in male and female Sprague-Dawley rats and Syrian golden hamsters. Drug Metab Dispos. 1999 Jan;27(1):138-46.Pubmed Abstract
    • Citation: Thomas BF, Burgess JP, Coleman DP, Scheffler NM, Jeffcoat AR, Dix KJ. Isolation and identification of novel metabolites of gemfibrozil in rat urine. Drug Metab Dispos. 1999 Jan;27(1):147-57.Pubmed Abstract
    • Male and Female Rats: Sprague Dawley; Rats: Sprague Dawley; Male and Female Hamsters: Syrian Golden