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Testing Status of Sodium arsenite M940036

 

CASRN: 7784-46-5

Formula: As-H-O2.Na

Synonyms/Common Names

  • Sodium meta-arsenite

Planned Carcinogenicity/Toxicity

  • 14 days (Gavage) Selected (C94036B)  
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 0.5, 1, 2.5, 5 mg/kg.
  • 1 day (Gavage) Selected (C94036C)  
    • Series Dose Escalation Cardiovascular Functional Assessment Study
    • Rats: Hsd:Sprague Dawley SD
    • Dose: Dose escalation, Single dose + recovery per dose level 0, 0.1, 0.5, 1, 2.5, 5 mg/kg.

Special Studies

  • C. elegans  (S0946)  Completed 
    • C. elegans
  • acute Toxicokinetic Study (Gavage; Dosed-Water; Dosed-Feed)  (K94036)  Completed 
    • Rats: CD; Mice: CD-1 Reg.[Crl:CD1(ICR)]; Monkeys: Rhesus
    • Dose: (all routes) 0, 0.05, 0.1, or 0.2 mg/kg, range finding [R,M,MO].

Genetic Toxicology

  • 3 days Comet Assay (Gavage)  (G94036)  Completed 
    • Rats: Sprague Dawley

Organ Systems Toxicity

  • 14 days Immunotoxicity (Subcutaneous Injection)  (IMM94004)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0.01, 0.03, 0.06 MG/ML.