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Testing Status of Bisphenol S M940150


CASRN: 80-09-1

Formula: C12-H10-O4-S

Synonyms/Common Names

  • Bis(4-hydroxyphenyl)sulfone
  • 4,4'-Bisphenol S
  • 4,4'-Dihydroxydiphenyl sulfone
  • Phenol, 4,4'-sulfonylbis-
  • 1,1'-Sulfonylbis(4-hydroxybenzene)

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C94150)  Report in Preparation 
    • Dose Range-Finding
    • Mice: B6C3F1
    • Dose: 0, 600, 1200, 2500, or 5000 ppm; 5/sex/group.

Modified One-Generation

  • GD 6 to PND 28 Dose Range Finding (Dosed-Feed)  (MOG94150)  Completed 
    • Perinatal Dose Range-Finding Study in Bisphenol S in Dosed Feed
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10, 000, 15, 000 or 20, 000 ppm.
  • 90 days F0 Generation (Gavage)  (MOG94150B)  Completed 
    • Modified One-generation Study (MOG94150) of Bisphenol S (CAS# 80-09-1) in Sprague Dawley Rats Exposed Dosed Feed
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage; Intravenous)  (K94150)  Completed 
    • Citation: Waidyanatha S, Black SR, Snyder RW, Yueh YL, Sutherland V, Patel PR, Watson SL, Fennell TR. Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans. Toxicol Appl Pharmacol. 2018 Jul 15;351:32-45. doi: 10.1016/j.taap.2018.05.008. Epub 2018 May 18.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 50 mg/kg. 50, 150, 500 mg/kg.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K94150B)  Completed 
    • Citation: Waidyanatha S, Black SR, Silinski M, Sutherland V, Fletcher BL, Fernando RA, Fennell TR. Comparative toxicokinetics of bisphenol S in rats and mice following gavage administration. Toxicol Appl Pharmacol. 2020 Nov 1;406:115207. doi: 10.1016/j.taap.2020.115207. Epub 2020 Aug 24.Pubmed Abstract
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N; Male and Female Mice: B6C3F1/N
    • Dose: 34 mg/kg. 34, 110, 340 mg/kg (male) 110 mg/kg (female).
  • Repeat (7 days) Toxicokinetic Study (Dosed-Feed)  (K94150C)  Completed 
    • Citation: Waidyanatha S, Black SR, Croutch CR, Collins BJ, Silinski MAR, Kerns S, Sutherland V, Robinson VG, Aillon K, Fernando RA, Mutlu E, Fennell TR. Comparative toxicokinetics of bisphenol S and bisphenol AF in male rats and mice following repeated exposure via feed. Xenobiotica. 2020 Oct 6:1-12. doi: 10.1080/00498254.2020.1829171. Epub ahead of print.Pubmed Abstract
    • Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N
    • Dose: 338, 1125, 3750 ppm.

Genetic Toxicology

  • 28 days Micronucleus (Dosed-Feed)  (G94150)  Completed 
    • Female Rats
    • Rats: Sprague Dawley
  • 28 days Micronucleus (Transplacental & Dosed Feed)  (G94150B)  Completed 
    • Rats: Harlan Sprague-Dawley