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Testing Status of Bisphenol S M940150

 

CASRN: 80-09-1

Formula: C12-H10-O4-S

Synonyms/Common Names

  • Bis(4-hydroxyphenyl)sulfone
  • 4,4'-Bisphenol S
  • 4,4'-Dihydroxydiphenyl sulfone
  • DIPHONE
  • Phenol, 4,4'-sulfonylbis-
  • 1,1'-Sulfonylbis(4-hydroxybenzene)

Short-Term Toxicity

  • 14 days (Dosed-Feed)  (C94150)  Report in Preparation 
    • Dose Range-Finding
    • Mice: B6C3F1
    • Dose: 0, 600, 1200, 2500, or 5000 ppm; 5/sex/group.

Modified One-Generation

  • GD 6 - PND 28 Dose Range Finding (Dosed-Feed)  (MOG94150)  Data in Review 
    • Perinatal Dose Range-Finding Study in Bisphenol S in Dosed Feed
    • Rats: Harlan Sprague-Dawley
    • Dose: 0, 5000, 10, 000, 15, 000 or 20, 000 ppm.
  • 90 days F0 Generation (Gavage)  (MOG94150B)  Data in Review 
    • Modified One-generation Study (MOG94150) of Bisphenol S (CAS# 80-09-1) in Sprague Dawley Rats Exposed Dosed Feed
    • Rats: Harlan Sprague-Dawley

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Gavage; Intravenous)  (K94150)  Completed 
    • Citation: Waidyanatha S, Black SR, Snyder RW, Yueh YL, Sutherland V, Patel PR, Watson SL, Fennell TR. Disposition and metabolism of the bisphenol analogue, bisphenol S, in Harlan Sprague Dawley rats and B6C3F1/N mice and in vitro in hepatocytes from rats, mice, and humans. Toxicol Appl Pharmacol. 2018 Jul 15;351:32-45. doi: 10.1016/j.taap.2018.05.008. Epub 2018 May 18.Pubmed Abstract
    • Male and Female Rats: Harlan Sprague-Dawley; Male and Female Mice: B6C3F1/N
    • Dose: 50 mg/kg. 50, 150, 500 mg/kg.
  • Toxicokinetic Study (Gavage; Intravenous; Gavage; Intravenous)  (K94150B)  Completed 
    • Rats: Harlan Sprague-Dawley; Mice: B6C3F1/N; Male and Female Mice: B6C3F1/N
    • Dose: 34 mg/kg. 34, 110, 340 mg/kg (male) 110 mg/kg (female).
  • Repeat (7 days) Toxicokinetic Study (Dosed-Feed)  (K94150C)  Completed 
    • Male Rats: Harlan Sprague-Dawley; Male Mice: B6C3F1/N
    • Dose: 338, 1125, 3750 ppm.

Genetic Toxicology

  • Micronucleus  (G94150)  Completed 
    • Female Rats
    • Rats: Sprague Dawley
  • Micronucleus  (G94150B)  Completed 
    • Rats: Harlan Sprague-Dawley