Testing Status of Tamoxifen citrate M960002
CASRN: 54965-24-1
Related: TAMOXIFEN (10540-29-1)
Formula: C26-H29-N-O.C6-H8-O7
Synonyms/Common Names
- 2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-,(Z)-, 2-hydroxy-1,2,3-oropanetricarboxylate (1:1)(9CI)
- Nolvadex
- TMX
- (Z)-(2-(4-(1,2-Diphenylbut-1-enyl)phenoxy)ethyl)dimethylammonium dihydrogen
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0617)
Completed
- Female Rats: F344/N
- Dose: SA: gav: 0.1 and 0.3 mg/kg, IV: 0.3 mg/kg RD: gav: 0.1 and 0.3 mg/kg, gav/IV (final dose only): 0.3 mg/kg.
- C. elegans
(S0885)
Completed
- C. elegans
- Dose: Feeding: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250)uMRepro: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM Growth: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM.
- Toxicokinetic Study (Gavage)
(S0598)
Completed
- Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats. August 8, 1997.
- Male Rats: Sprague Dawley
- Dose: iv and gavage gav: 0.01 mg/kg in dose volume 5 mL/kg.
- Toxicokinetic Study (Gavage; Intravenous)
(S0916)
Completed
- Female Rats: F344/N
- Dose: 100, 300 ug/kg ; 300 ug/kg.
- Toxicokinetic Study (Gavage; Intravenous)
(S0917)
Completed
- Male and Female Rats: Sprague Dawley
- Dose: 10, 100, 300 ug/kg ; 300 ug/kg.
Organ Systems Toxicity
- 14 weeks Continuous Breeding (Legacy) (Gavage)
(RACB95003)
Completed
- Male and Female Rats: Sprague Dawley
- Dose: 0, .003, .01, OR .03.