Testing Status of Tamoxifen citrate M960002

CASRN: 54965-24-1

Related: TAMOXIFEN (10540-29-1)

Formula: C26-H29-N-O.C6-H8-O7

Synonyms/Common Names

• 2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethyl-,(Z)-, 2-hydroxy-1,2,3-oropanetricarboxylate (1:1)(9CI)
• Nolvadex
• TMX
• (Z)-(2-(4-(1,2-Diphenylbut-1-enyl)phenoxy)ethyl)dimethylammonium dihydrogen

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0617)  Completed 
  • Female Rats: F344/N
  • Dose: SA: gav: 0.1 and 0.3 mg/kg, IV: 0.3 mg/kg RD: gav: 0.1 and 0.3 mg/kg, gav/IV (final dose only): 0.3 mg/kg.
• Toxicokinetic Study (Gavage)  (S0598)  Completed 
  • Citation: Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats. August 8, 1997.
  • Male Rats: Sprague Dawley
  • Dose: iv and gavage gav: 0.01 mg/kg in dose volume 5 mL/kg.
• Toxicokinetic Study (Gavage; Intravenous)  (S0916)  Completed 
  • Female Rats: F344/N
  • Dose: 100, 300 ug/kg ; 300 ug/kg.
• Toxicokinetic Study (Gavage; Intravenous)  (S0917)  Completed 
  • Male and Female Rats: Sprague Dawley
  • Dose: 10, 100, 300 ug/kg ; 300 ug/kg.
• C. elegans  (S0885)  Completed 
  • C. elegans
  • Dose: Feeding: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250)uMRepro: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM Growth: (0, 2.5, 4, 6.3, 10, 16, 25, 40, 63, 100, 160, 250) uM.

Organ Systems Toxicity

• 14 weeks Continuous Breeding (Legacy) (Gavage)  (RACB95003)  Completed 
  • Male and Female Rats: Sprague Dawley
  • Dose: 0, .003, .01, OR .03.