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Testing Status of Propargyl alcohol M960126

 

CASRN: 107-19-7

Formula: C3-H4-O

Synonyms/Common Names

  • Ethynyl carbinol
  • Propynl alcohol
  • 2-Propyn-1-ol (8CI, 9CI)

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C97008)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 31.25, 62.5, 125, 250, OR 500 PPM; 5/SEX/SPECIES.
  • 13 weeks (Inhalation)  (C97008)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 4, 8, 16, 32, OR 64 PPM R: 20/SEX M: 10/SEX.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C97008)  Completed 
    • TR-552 (NIH Number: 08-5893)  (Peer Review Approval 05/17/2007A )
      Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 16, 32, OR 64 PPM M: 0, 8, 16, OR 32 PPM; 50/SEX/SPECIES.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application; Intravenous; Inhalation; Gavage; Intravenous; Inhalation)  (S0815)  Completed 
    • Male Rats: F344/N; Male Mice: B6C3F1
    • Dose: Rats:inhal:one 6-hr nose-only @ 1 ppm; one 6-hr nose-only @ 100 ppm Mice:inhal:one 6-hr nose-only @ 1 ppm; one 6-hr nose-only @ 100 ppm Rats:IV:single 1 mg/kg Mice:IV:single 1 mg/kg Rats:ORAL:50 mg/kg Mice:ORAL:50 mg/kg Rats:DERMAL:0.5 and 5 mg/kg Rats:DERMAL:0.05, 0.5 and 5 mg/kg.

Genetic Toxicology

  • Micronucleus  (A41608)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (A70312)  Completed 
    •  Positive