Testing Status of bis(2-Chloroethoxy)methane M980065
CASRN: 111-91-1
Formula: C5-H10-Cl2-O2
Synonyms/Common Names
- CEM
- Dichloroethyl formal
- Ethane, 1,1'-(methylenebis(oxy))bis(2-chloro-
- Formaldehyde bis(2-chloroethyl) acetal
Short-Term Toxicity
- 2 weeks (Topical Application)
(C99028)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/KG; 5/SEX/DOSE.
- 3 days (Gavage)
(C99028B)
Completed
- Mice: B6C3F1
- Dose: MM: 0, 50, 100, 150, 200, or 300 mg/kg.
- 10 days (Gavage)
(C99028C)
Completed
- Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
- Dose: Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 150, 200, or 300 mg/kg.
- 3 days (Gavage)
(C99028C)
Completed
- Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
- Dose: Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J, : 0, 150, 200, or 300 mg/kg. Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 150, 200, or 300 mg/kg.
- 13 weeks (Topical Application)
(C99028)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 50, 100, 200, 400, OR 600 MG/KG; 10/SEX/DOSE.
Long-Term Carcinogenicity
- 2 years (Topical Application)
(C99028)
Completed
- TR-536 (NIH Number: 10-5904)
(Peer Review Approval 11/19/2009A )
Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CASRN 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice No Evidence
- Female Mice No Evidence
- Dose: R: 0, 75, 150, OR 300 MG/KG; MM: 0, 150, 300 OR 600 MG/KG; FM: 0, 100, 200, OR 400 MG/KG.
- TR-536 (NIH Number: 10-5904)
(Peer Review Approval 11/19/2009A )
Special Studies
- Absorption Distribution Metabolism Excretion (Gavage; Topical Application; Intravenous; Gavage; Topical Application; Intravenous)
(S0816)
Completed
- Citation: Black SR, Decosta KS, Patel PR, Mathews JM. [14C]bis(2-chloroethoxy)methane: comparative absorption, distribution, metabolism and excretion in rats and mice. Xenobiotica. 2007 37(4):427-40. doi: 10.1080/00498250701206872.Pubmed Abstract
- Male Rats: F344/N; Male and Female Mice: B6C3F1
- Dose: (all routes) 0.1, 1, 10 mg/kg [R,M].
- Toxicokinetic Study (Dermal; Intravenous; Dermal; Intravenous)
(K08624)
Completed
- Citation: Waidyanatha S, Johnson JD, Hong SP, Godfrey-Robinson VD, Graves SW, Cristy T, Dunnick JK, Smith CS. Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice. Toxicol Lett. 2011 Aug 28;205(2):215-26. doi: 10.1016/j.toxlet.2011.06.012. Epub 2011 Jun 17.Pubmed Abstract
- Rats: Fischer 344; Mice: B6C3F1
Genetic Toxicology
- Micronucleus
(A22073)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Micronucleus
(A53820)
Completed
- Rats: Fischer 344
- Male Negative
- Salmonella
(A20931)
Completed
- Equivocal
- Salmonella
(A92025)
Completed
- Positive