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Testing Status of bis(2-Chloroethoxy)methane M980065

 

CASRN: 111-91-1

Formula: C5-H10-Cl2-O2

Synonyms/Common Names

  • CEM
  • Dichloroethyl formal
  • Ethane, 1,1'-(methylenebis(oxy))bis(2-chloro-
  • Formaldehyde bis(2-chloroethyl) acetal

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C99028)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/KG; 5/SEX/DOSE.
  • 3 days (Gavage)  (C99028B)  Completed 
    • Mice: B6C3F1
    • Dose: MM: 0, 50, 100, 150, 200, or 300 mg/kg.
  • 10 days (Gavage)  (C99028C)  Completed 
    • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
    • Dose: Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 150, 200, or 300 mg/kg.
  • 3 days (Gavage)  (C99028C)  Completed 
    • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
    • Dose: Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J, : 0, 150, 200, or 300 mg/kg. Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 150, 200, or 300 mg/kg.
  • 13 weeks (Topical Application)  (C99028)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 50, 100, 200, 400, OR 600 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C99028)  Completed 
    • TR-536 (NIH Number: 10-5904)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CASRN 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 75, 150, OR 300 MG/KG; MM: 0, 150, 300 OR 600 MG/KG; FM: 0, 100, 200, OR 400 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Topical Application; Intravenous; Gavage; Topical Application; Intravenous)  (S0816)  Completed 
    • Citation: Black SR, Decosta KS, Patel PR, Mathews JM. [14C]bis(2-chloroethoxy)methane: comparative absorption, distribution, metabolism and excretion in rats and mice. Xenobiotica. 2007 37(4):427-40. doi: 10.1080/00498250701206872.Pubmed Abstract
    • Male Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: 0.1, 1, 10 mg/kg.
  • Toxicokinetic Study (Dermal; Intravenous; Dermal; Intravenous)  (K08624)  Completed 
    • Citation: Waidyanatha S, Johnson JD, Hong SP, Godfrey-Robinson VD, Graves SW, Cristy T, Dunnick JK, Smith CS. Toxicokinetics of bis(2-chloroethoxy)methane following intravenous administration and dermal application in male and female F344/N rats and B6C3F1 mice. Toxicol Lett. 2011 Aug 28;205(2):215-26. doi: 10.1016/j.toxlet.2011.06.012. Epub 2011 Jun 17.Pubmed Abstract
    • Rats: Fischer 344; Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A22073)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A53820)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (A20931)  Completed 
    •  Equivocal 
  • Salmonella  (A92025)  Completed 
    •  Positive